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UL114 uracil-DNA glycosylase [ Human betaherpesvirus 5 ]

Gene ID: 3077539, updated on 20-Nov-2023

Summary

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Gene symbol
UL114
Gene description
uracil-DNA glycosylase
Locus tag
HHV5wtgp100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human betaherpesvirus 5 (strain: Merlin, acronym: HHV-5; HCMV, nat-host: Homo sapiens, culture-collection: ATCC:VR-1590)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus
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Genomic context

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Sequence:
NC_006273.2 (164298..165050, complement)

NC_006273.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene interleukin-10 Neighboring gene protein UL112 Neighboring gene envelope glycoprotein L Neighboring gene protein UL116 Neighboring gene protein UL117 Neighboring gene membrane glycoprotein UL119

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006273.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54. Strang BL, et al. J Gen Virol, 2010 Aug. PMID 20410316, Free PMC Article
  2. Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44). Ranneberg-Nilsen T, et al. J Mol Biol, 2008 Aug 29. PMID 18599070
  3. Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA. Prichard MN, et al. Virol J, 2005 Jul 15. PMID 16022730, Free PMC Article
  4. The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44. Ranneberg-Nilsen T, et al. PLoS One, 2012. PMID 22479537, Free PMC Article
  5. High-resolution human cytomegalovirus transcriptome. Gatherer D, et al. Proc Natl Acad Sci U S A, 2011 Dec 6. PMID 22109557, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44
    Title: The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44.
  2. Utilizing virus expressing FLAG-tagged UL114, nuclease-resistant association of UL44 and the DNA polymerase catalytic subunit UL54 with UL114 was observed by co-immunoprecipitation.
    Title: Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54.
  3. pUL114 associates with ppUL44 and it functions as part of the viral DNA replication complex to increase the efficiency of both early and late phase viral DNA synthesis.
    Title: Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA.
  4. Data demonstrated a catalytically inefficient viral uracil DNA glycosylase that was highly enriched in viral replication foci, thus supporting an important role of UL114 in replication rather than repair of the viral genome.
    Title: Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44).
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • core gene

General protein information

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Preferred Names
uracil-DNA glycosylase
YP_081554.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006273.2 Reference assembly

    Range
    164298..165050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_081554.1 uracil-DNA glycosylase [Human betaherpesvirus 5]

    See identical proteins and their annotated locations for YP_081554.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HI85, P16769, Q7M6T0
    UniProtKB/TrEMBL
    A0A0G2TRP5, A0A0G2UCD5, A0A140D1V3, A8T7J5, B8YED1, B9VXR4, C8BKQ3, C8CFE5, D2K3R4, D2K5K2, D3YS27, Q6RXD1, Q6SW36, V9LLW5, V9LN82
    Conserved Domains (2) summary
    PHA03200
    Location:1 → 250
    PHA03200; uracil DNA glycosylase; Provisional
    cd10027
    Location:89 → 93
    UDG-F1-like; motif A [structural motif]
Nucleotide Protein
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