Otud4 OTU deubiquitinase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Otud4provided by RGD
Official Full Name: OTU deubiquitinase 4provided by RGD
Primary source: RGD:1305606
See related: Ensembl:ENSRNOG00000018477 AllianceGenome:RGD:1305606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305606
Summary: Predicted to enable Lys63-specific deubiquitinase activity; molecular adaptor activity; and thiol-dependent deubiquitinase. Predicted to be involved in several processes, including negative regulation of signal transduction; positive regulation of DNA demethylation; and protein deubiquitination. Predicted to be located in cytosol. Orthologous to human OTUD4 (OTU deubiquitinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 187.8), Thymus (RPKM 179.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (45141043..45184136, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (28236713..28279815, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (31895753..31942509, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA alkylation repair	IEA Inferred from Electronic Annotation more info
involved_in DNA alkylation repair	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein K48-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: OTU domain-containing protein 4

Names: OTU domain containing 4

NP_001178629.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191700.1 → NP_001178629.1 OTU domain-containing protein 4

Status: VALIDATED

Source sequence(s)

BF284741, JAXUCZ010000019

UniProtKB/TrEMBL

F1M7Q7

Related

ENSRNOP00000024924.6, ENSRNOT00000024924.7

Conserved Domains (2) summary

pfam12293
Location:556 → 642

T4BSS_DotH_IcmK; Putative outer membrane core complex of type IVb secretion

cl19932
Location:42 → 121

OTU; OTU-like cysteine protease