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Jph3 junctophilin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307916, updated on 5-Mar-2024

Summary

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Official Symbol
Jph3provided by RGD
Official Full Name
junctophilin 3provided by RGD
Primary source
RGD:1308416
See related
Ensembl:ENSRNOG00000018784 AllianceGenome:RGD:1308416
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including exploration behavior; memory; and regulation of ryanodine-sensitive calcium-release channel activity. Predicted to act upstream of or within several processes, including learning; neuromuscular process controlling balance; and regulation of neuronal synaptic plasticity. Predicted to be located in endoplasmic reticulum. Predicted to be part of junctional membrane complex. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Human ortholog(s) of this gene implicated in Huntington's disease-like 2. Orthologous to human JPH3 (junctophilin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 273.0) See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (66702497..66763948)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (49793967..49855338)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (54553419..54613477)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483656 Neighboring gene uncharacterized LOC102550418 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene kelch domain containing 4 Neighboring gene microRNA 3564 Neighboring gene solute carrier family 7 member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Motor discoordination in mutant mice lacking junctophilin type 3. Nishi M, et al. Biochem Biophys Res Commun, 2002 Mar 29. PMID 11906164
  2. Homer1a is a core brain molecular correlate of sleep loss. Maret S, et al. Proc Natl Acad Sci U S A, 2007 Dec 11. PMID 18077435, Free PMC Article
  3. Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. Moriguchi S, et al. Proc Natl Acad Sci U S A, 2006 Jul 11. PMID 16809425, Free PMC Article
  4. Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. Kakizawa S, et al. EMBO J, 2007 Apr 4. PMID 17347645, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in exploration behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within learning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within locomotion ISO
Inferred from Sequence Orthology
more info
  
involved_in memory ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of junctional membrane complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of junctional membrane complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
junctophilin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107437.1 → NP_001100907.1  junctophilin-3

    See identical proteins and their annotated locations for NP_001100907.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A6IZQ1, D3ZWH2
    Related
    ENSRNOP00000025392.4, ENSRNOT00000025392.6
    Conserved Domains (1) summary
    pfam02493
    Location:311 → 333
    MORN; MORN repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    66702497..66763948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097780.2 → XP_038953708.1  junctophilin-3 isoform X1

    Conserved Domains (1) summary
    PLN03185
    Location:5 → 144
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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