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Tagap T-cell activation RhoGTPase activating protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 308097, updated on 30-Mar-2024

Summary

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Official Symbol
Tagapprovided by RGD
Official Full Name
T-cell activation RhoGTPase activating proteinprovided by RGD
Primary source
RGD:1308618
See related
Ensembl:ENSRNOG00000018915 AllianceGenome:RGD:1308618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of catalytic activity and signal transduction. Predicted to act upstream of or within defense response to virus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus 21. Orthologous to human TAGAP (T cell activation RhoGTPase activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 79.8), Uterus (RPKM 77.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tagap in Genome Data Viewer
Location:
1q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49575750..49584747, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (47170725..47179705, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47493990..47503492, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 546 Neighboring gene radial spoke head 3 Neighboring gene uncharacterized LOC120099118 Neighboring gene uncharacterized LOC102551987

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse. Liao J, et al. PLoS One, 2014. PMID 25268627, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development.
    Title: TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-cell activation Rho GTPase-activating protein
Names
T-cell activation GTPase activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309449.1 → NP_001296378.1  T-cell activation Rho GTPase-activating protein

    See identical proteins and their annotated locations for NP_001296378.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A128DYU5, A6KP20, D3ZXG5
    Conserved Domains (1) summary
    cd04402
    Location:85 → 281
    RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    49575750..49584747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003748695.6 → XP_003748743.1  T-cell activation Rho GTPase-activating protein isoform X1

    See identical proteins and their annotated locations for XP_003748743.1

    UniProtKB/TrEMBL
    A0A128DYU5, A6KP20, D3ZXG5
    Related
    ENSRNOP00000025580.6
    Conserved Domains (1) summary
    cd04402
    Location:85 → 281
    RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...

  2. XM_006227912.5 → XP_006227974.1  T-cell activation Rho GTPase-activating protein isoform X2

    See identical proteins and their annotated locations for XP_006227974.1

    UniProtKB/TrEMBL
    A0A128DYU5
    Conserved Domains (1) summary
    cd04402
    Location:79 → 275
    RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107455.1: Suppressed sequence

    Description
    NM_001107455.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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