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Strn4 striatin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308392, updated on 13-Apr-2024

Summary

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Official Symbol
Strn4provided by RGD
Official Full Name
striatin 4provided by RGD
Primary source
RGD:1307030
See related
Ensembl:ENSRNOG00000016145 AllianceGenome:RGD:1307030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein domain specific binding activity. Located in dendritic spine. Part of protein-containing complex. Orthologous to human STRN4 (striatin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 195.0), Heart (RPKM 132.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Strn4 in Genome Data Viewer
Location:
1q21
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (86614193..86639959)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (77482267..77511862)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78739930..78765696)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099772 Neighboring gene solute carrier family 1 member 5 Neighboring gene fukutin related protein Neighboring gene transfer RNA proline (anticodon CGG) Neighboring gene protein kinase D2 Neighboring gene dishevelled-binding antagonist of beta-catenin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A. Lin L, et al. J Biol Chem, 2017 Jun 9. PMID 28442576, Free PMC Article
  2. Distribution of zinedin in the rat brain. Benoist M, et al. J Neurochem, 2008 Jul. PMID 18466332
  3. Targeting of proteins of the striatin family to dendritic spines: role of the coiled-coil domain. Gaillard S, et al. Traffic, 2006 Jan. PMID 16445688
  4. Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines. Baillat G, et al. Mol Biol Cell, 2001 Mar. PMID 11251078, Free PMC Article
  5. Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1. Gaillard S, et al. FEBS Lett, 2001 Nov 9. PMID 11707266

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STRN4 is preferentially expressed in mushroom spines, and STRN4 specifically maintains mushroom spines but not thin spines and filopodia through interaction with the phosphatase PP2A
    Title: Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables armadillo repeat domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
striatin-4
Names
striatin, calmodulin binding protein 4
zinedin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107480.2 → NP_001100950.2  striatin-4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BQ198897, JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AK86, F1M6V8
    Related
    ENSRNOP00000021976.3, ENSRNOT00000021976.6
    Conserved Domains (4) summary
    COG2319
    Location:422 → 752
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:436 → 758
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:63 → 188
    Striatin; Striatin family
    sd00039
    Location:449 → 495
    7WD40; WD40 repeat [structural motif]

  2. NM_001161809.1 → NP_001155281.1  striatin-4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal 7-aa segment, compared to isoform 1.
    Source sequence(s)
    BC168948, BF408712, BQ198897, JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AK86
    Conserved Domains (4) summary
    COG2319
    Location:415 → 745
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:429 → 751
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:63 → 188
    Striatin; Striatin family
    sd00039
    Location:442 → 488
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    86614193..86639959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111193.2 → XP_038967121.1  striatin-4 isoform X2

    Conserved Domains (1) summary
    pfam08232
    Location:64 → 188
    Striatin; Striatin family

  2. XM_063261295.1 → XP_063117365.1  striatin-4 isoform X1

    UniProtKB/TrEMBL
    F1M6V8

RNA

  1. XR_010051831.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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