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Coq8b coenzyme Q8B [ Rattus norvegicus (Norway rat) ]

Gene ID: 308453, updated on 5-Mar-2024

Summary

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Official Symbol
Coq8bprovided by RGD
Official Full Name
coenzyme Q8Bprovided by RGD
Primary source
RGD:1311356
See related
Ensembl:ENSRNOG00000020848 AllianceGenome:RGD:1311356
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Adck4
Summary
Predicted to enable kinase activity. Predicted to be involved in cerebellar Purkinje cell layer morphogenesis and ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Predicted to be extrinsic component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9. Orthologous to human COQ8B (coenzyme Q8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 111.6), Testes (RPKM 77.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Coq8b in Genome Data Viewer
Location:
1q21
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (91653241..91676822)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82525578..82549182)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (84043487..84067066)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide A Neighboring gene actin maturation protease Neighboring gene inositol-trisphosphate 3-kinase C Neighboring gene NUMB-like, endocytic adaptor protein Neighboring gene ribosomal protein L14, pseudogene 3 Neighboring gene uncharacterized LOC120099779 Neighboring gene small nuclear ribonucleoprotein G-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity. Stefely JA, et al. Mol Cell, 2016 Aug 18. PMID 27499294, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cerebellar Purkinje cell layer morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebellar Purkinje cell layer morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
atypical kinase COQ8B, mitochondrial
Names
aarF domain containing kinase 4
aarF domain-containing protein kinase 4
coenzyme Q protein 8B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012065.1 → NP_001012065.1  atypical kinase COQ8B, mitochondrial

    See identical proteins and their annotated locations for NP_001012065.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079227
    UniProtKB/Swiss-Prot
    Q6AY19
    UniProtKB/TrEMBL
    A0A8I6AH42
    Related
    ENSRNOP00000028290.6, ENSRNOT00000028290.7
    Conserved Domains (1) summary
    cd13970
    Location:171 → 420
    ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    91653241..91676822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261398.1 → XP_063117468.1  atypical kinase COQ8B, mitochondrial isoform X3

  2. XM_017589119.3 → XP_017444608.1  atypical kinase COQ8B, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6AY19
    UniProtKB/TrEMBL
    A0A8I6AH42
    Conserved Domains (1) summary
    cd13970
    Location:171 → 420
    ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

  3. XM_039111525.2 → XP_038967453.1  atypical kinase COQ8B, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:171 → 294
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039111513.2 → XP_038967441.1  atypical kinase COQ8B, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd13970
    Location:17 → 266
    ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

  5. XM_063261396.1 → XP_063117466.1  atypical kinase COQ8B, mitochondrial isoform X2

  6. XM_063261394.1 → XP_063117464.1  atypical kinase COQ8B, mitochondrial isoform X2

RNA

  1. XR_005505196.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY19.1 GenPept UniProtKB/Swiss-Prot:Q6AY19

Gene LinkOut

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