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Wdr62 WD repeat domain 62 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308492, updated on 30-Mar-2024

Summary

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Symbol
Wdr62provided by RGD
Full Name
WD repeat domain 62provided by RGD
Primary source
RGD:1306714
See related
Ensembl:ENSRNOG00000020807 AllianceGenome:RGD:1306714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306714
Summary
Involved in several processes, including positive regulation of neuroblast proliferation; positive regulation of neuron migration; and regulation of centrosome cycle. Predicted to be located in centriolar satellite and cytosol. Predicted to be active in nucleus and spindle pole. Human ortholog(s) of this gene implicated in intellectual disability; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 92.6), Thymus (RPKM 20.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q21
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94618992..94658097, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85491531..85530643, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (90995545..91034592)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit I Neighboring gene ovo-like zinc finger 3 Neighboring gene uncharacterized LOC120096980 Neighboring gene THAP domain containing 8 Neighboring gene CAP-GLY domain containing linker protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel splice-site mutation in WDR62 revealed by whole-exome sequencing in a Sudanese family with primary microcephaly. Bastaki F, et al. Congenit Anom (Kyoto), 2016 May. PMID 26577670
  2. A novel single base pair duplication in WDR62 causes primary microcephaly. Rupp V, et al. BMC Med Genet, 2014 Oct 11. PMID 25303973, Free PMC Article
  3. The utility of exome sequencing for genetic diagnosis in a familial microcephaly epilepsy syndrome. McDonell LM, et al. BMC Neurol, 2014 Jan 31. PMID 24479948, Free PMC Article
  4. WDR62 missense mutation in a consanguineous family with primary microcephaly. Bacino CA, et al. Am J Med Genet A, 2012 Mar. PMID 22308068
  5. Mutations in WDR62 gene in Pakistani families with autosomal recessive primary microcephaly. Kousar R, et al. BMC Neurol, 2011 Oct 1. PMID 21961505, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebral cortex development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 62
Names
WD repeat domain 62-like 1
WD repeat-containing protein 62-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191623.2 → NP_001178552.2  WD repeat-containing protein 62

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1LRR4, F1M5K2
    Related
    ENSRNOP00000061740.2, ENSRNOT00000065011.3
    Conserved Domains (3) summary
    COG2319
    Location:437 → 745
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:538 → 579
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:493 → 745
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    94618992..94658097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228797.4 → XP_006228859.1  WD repeat-containing protein 62 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JZG6, F1LRR4
    Related
    ENSRNOP00000071039.2
    Conserved Domains (3) summary
    COG2319
    Location:437 → 745
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:538 → 579
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:493 → 745
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_039111586.2 → XP_038967514.1  WD repeat-containing protein 62 isoform X1

    UniProtKB/TrEMBL
    F1LRR4
    Conserved Domains (3) summary
    PHA03247
    Location:1032 → 1438
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:538 → 579
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:493 → 745
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_039111587.2 → XP_038967515.1  WD repeat-containing protein 62 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:585 → 627
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:493 → 745
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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