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Rhog ras homolog family member G [ Rattus norvegicus (Norway rat) ]

Gene ID: 308875, updated on 3-Apr-2024

Summary

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Official Symbol
Rhogprovided by RGD
Official Full Name
ras homolog family member Gprovided by RGD
Primary source
RGD:621310
See related
Ensembl:ENSRNOG00000020393 AllianceGenome:RGD:621310
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arhg
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; activation of GTPase activity; and cytoskeleton organization. Predicted to act upstream of or within several processes, including Rho protein signal transduction; positive regulation of transcription, DNA-templated; and regulation of ruffle assembly. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Orthologous to human RHOG (ras homolog family member G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 120.2), Thymus (RPKM 108.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhog in Genome Data Viewer
Location:
1q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (166030685..166046254, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156618713..156630710, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167336147..167347720, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene glutathione peroxidase 4, pseudogene 1 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ribosomal protein S29, pseudogene 1 Neighboring gene stromal interaction molecule 1 Neighboring gene ribosome biogenesis protein NSA2 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Developmental changes in expression of small GTPase RhoG mRNA in the rat brain. Ishikawa Y, et al. Brain Res Mol Brain Res, 2002 Oct 15. PMID 12393274
  2. miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling. Franke K, et al. EMBO J, 2012 Jun 29. PMID 22588079, Free PMC Article
  3. RhoG regulates gene expression and the actin cytoskeleton in lymphocytes. Vigorito E, et al. Oncogene, 2003 Jan 23. PMID 12545154
  4. RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model. Ubba V, et al. Reprod Sci, 2017 May. PMID 27662902
  5. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons. Kim JY, et al. J Biol Chem, 2011 Oct 28. PMID 21900250, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rac1, Cdc42, and RhoG perform very specific and non-redundant functions at different levels of hierarchy in regulating dendritic tree complexity induced by CALEB/NGC
    Title: Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity.
  2. RHOG can mediate signaling through downstream effectors DOCK1 and RAC1 during ovarian follicular development (theca and granulosa cells and oocyte), but dehydroepiandrosterone downregulated them in the polycystic ovarian syndrome ovary.
    Title: RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model.
  3. Dock3 forms a complex with Elmo and activated RhoG downstream of BDNF-TrkB signaling and induces neurite outgrowth via Rac1 activation in PC12 cells.
    Title: Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG.
  4. RhoG emerges as a cellular conductor of Rac1 and Cdc42 activity, in turn regulated by miR-124 to control axonal and dendritic branching.
    Title: miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.
  5. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
    Title: The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
  6. Fibroblast growth factor 2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha.
    Title: Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.
  7. results suggest distinct pre- and postnatal roles in the development of the central nervous system
    Title: Developmental changes in expression of small GTPase RhoG mRNA in the rat brain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125105

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in cortical cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho-related GTP-binding protein RhoG
Names
ras homolog gene family, member G (rho G)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037195.1 → NP_001032272.1  rho-related GTP-binding protein RhoG

    See identical proteins and their annotated locations for NP_001032272.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107943
    UniProtKB/TrEMBL
    A0A8I6A3A8, Q32PX6
    Related
    ENSRNOP00000086185.1, ENSRNOT00000101823.1
    Conserved Domains (1) summary
    cd01875
    Location:1 → 191
    RhoG; Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    166030685..166046254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229882.5 → XP_006229944.1  rho-related GTP-binding protein RhoG isoform X1

    See identical proteins and their annotated locations for XP_006229944.1

    UniProtKB/TrEMBL
    A0A8I6A3A8, Q32PX6
    Related
    ENSRNOP00000096983.1
    Conserved Domains (1) summary
    cd01875
    Location:1 → 191
    RhoG; Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)

  2. XM_006229883.5 → XP_006229945.1  rho-related GTP-binding protein RhoG isoform X1

    See identical proteins and their annotated locations for XP_006229945.1

    UniProtKB/TrEMBL
    A0A8I6A3A8, Q32PX6
    Related
    ENSRNOP00000027641.3
    Conserved Domains (1) summary
    cd01875
    Location:1 → 191
    RhoG; Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)

  3. XM_063262837.1 → XP_063118907.1  rho-related GTP-binding protein RhoG isoform X1

    UniProtKB/TrEMBL
    A0A8I6A3A8, Q32PX6
Nucleotide Protein Strain
Heading Accession and Version

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