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Mrpl21 mitochondrial ribosomal protein L21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309140, updated on 5-Mar-2024

Summary

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Official Symbol
Mrpl21provided by RGD
Official Full Name
mitochondrial ribosomal protein L21provided by RGD
Primary source
RGD:1310203
See related
Ensembl:ENSRNOG00000013845 AllianceGenome:RGD:1310203
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of ribosome. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL21 (mitochondrial ribosomal protein L21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 89.6), Muscle (RPKM 81.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrpl21 in Genome Data Viewer
Location:
1q42
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (209958693..209987393)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (200529416..200542568)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (218532045..218545428)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member D Neighboring gene immunoglobulin mu DNA binding protein 2 Neighboring gene carnitine palmitoyltransferase 1A Neighboring gene uncharacterized LOC134483953 Neighboring gene testis expressed metallothionein like protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
  2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein bL21m
Names
39S ribosomal protein L21, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107567.1 → NP_001101037.1  large ribosomal subunit protein bL21m

    See identical proteins and their annotated locations for NP_001101037.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A6HYK0, A6HYK1, D3ZMR9
    Related
    ENSRNOP00000018848.3, ENSRNOT00000018848.5
    Conserved Domains (1) summary
    pfam00829
    Location:100 → 202
    Ribosomal_L21p; Ribosomal prokaryotic L21 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    209958693..209987393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760120.4 → XP_008758342.1  large ribosomal subunit protein bL21m isoform X1

    UniProtKB/TrEMBL
    A6HYK0
    Conserved Domains (1) summary
    pfam00829
    Location:106 → 182
    Ribosomal_L21p; Ribosomal prokaryotic L21 protein
Nucleotide Protein Strain
Heading Accession and Version

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