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ACACA acetyl-CoA carboxylase alpha [ Homo sapiens (human) ]

Gene ID: 31, updated on 7-Apr-2024

Summary

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Official Symbol
ACACAprovided by HGNC
Official Full Name
acetyl-CoA carboxylase alphaprovided by HGNC
Primary source
HGNC:HGNC:84
See related
Ensembl:ENSG00000278540 MIM:200350; AllianceGenome:HGNC:84
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACC; ACAC; ACC1; ACCA; Acac1; hACC1; ACACAD; ACCalpha; ACACalpha
Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 9.8), brain (RPKM 9.7) and 24 other tissues See more
Orthologs
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Genomic context

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See ACACA in Genome Data Viewer
Location:
17q12
Exon count:
66
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (37084992..37406836, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38071975..38396996, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35441927..35766927, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene apoptosis antagonizing transcription factor Neighboring gene MPRA-validated peak2828 silencer Neighboring gene uncharacterized LOC105371753 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35405396-35405896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35421791-35422346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35422902-35423456 Neighboring gene microRNA 2909 Neighboring gene NANOG hESC enhancer GRCh37_chr17:35446662-35447163 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:35453499-35454698 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35460987-35461591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35464014-35464618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35464619-35465223 Neighboring gene NANOG hESC enhancer GRCh37_chr17:35499293-35499794 Neighboring gene high mobility group box 1 pseudogene 24 Neighboring gene ribosomal protein S2 pseudogene 49 Neighboring gene ribosomal protein L18a pseudogene 12 Neighboring gene small nucleolar RNA, H/ACA box 90 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35712269-35712768 Neighboring gene chromosome 17 open reading frame 78 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35768105-35768789 Neighboring gene transcriptional adaptor 2A Neighboring gene ribosomal protein L24 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr17:35814497-35815074 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:35815591-35816092 Neighboring gene MPRA-validated peak2830 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35843239-35843740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35851097-35851882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867118-35867618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867619-35868119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35872759-35873272 Neighboring gene dual specificity phosphatase 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of acetyl-CoA carboxylase alpha as a prognostic and targeted candidate for hepatocellular carcinoma. Shen Y, et al. Clin Transl Oncol, 2023 Aug. PMID 36976490
  2. Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-κB-snail axis. Saisomboon S, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jun. PMID 36972768
  3. Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial β-oxidation in castration-resistant prostate cancer cells. Liu S, et al. J Biol Chem, 2023 Jan. PMID 36410440, Free PMC Article
  4. Circular RNA circ‑ACACA regulates proliferation, migration and glycolysis in non‑small‑cell lung carcinoma via miR‑1183 and PI3K/PKB pathway. Wu W, et al. Int J Mol Med, 2020 Jun. PMID 32236577, Free PMC Article
  5. Synthesis and anti-cancer activity of ND-646 and its derivatives as acetyl-CoA carboxylase 1 inhibitors. Li EQ, et al. Eur J Pharm Sci, 2019 Sep 1. PMID 31325544

See all (217) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA.
    Title: CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA.
  2. Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD.
    Title: Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD.
  3. Involvement of ACACA (acetyl-CoA carboxylase alpha) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts.
    Title: Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts.
  4. Identification of acetyl-CoA carboxylase alpha as a prognostic and targeted candidate for hepatocellular carcinoma.
    Title: Identification of acetyl-CoA carboxylase alpha as a prognostic and targeted candidate for hepatocellular carcinoma.
  5. Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-kappaB-snail axis.
    Title: Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-κB-snail axis.
  6. Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial beta-oxidation in castration-resistant prostate cancer cells.
    Title: Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial β-oxidation in castration-resistant prostate cancer cells.
  7. circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.
    Title: circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.
  8. [Research on the mechanism of hypoxia promoting the migration of lung adenocarcinoma A549 cells].
    Title: [Research on the mechanism of hypoxia promoting the migration of lung adenocarcinoma A549 cells].
  9. MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.
    Title: MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.
  10. ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
    Title: ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Acetyl-CoA: carboxylase deficiency
MedGen: C0268603 OMIM: 613933 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
EBI GWAS Catalog
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Gag interacts with ACACA as demonstrated by proximity dependent biotinylation proteomics PubMed
tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA carboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetyl-CoA carboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables acetyl-CoA carboxylase activity TAS
Traceable Author Statement
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to prostaglandin E stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IC
Inferred by Curator
more info
  
involved_in fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in lipid homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in malonyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tissue homeostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acetyl-CoA carboxylase 1
Names
ACC-alpha
acetyl-Coenzyme A carboxylase alpha
NP_942131.1
NP_942133.1
NP_942134.1
NP_942135.1
NP_942136.1
XP_005257324.1
XP_006721916.1
XP_011523003.1
XP_011523005.1
XP_011523006.1
XP_047291834.1
XP_047291835.1
XP_047291836.1
XP_047291837.1
XP_047291838.1
XP_047291839.1
XP_047291840.1
XP_047291841.1
XP_047291842.1
XP_047291844.1
XP_047291845.1
XP_047291846.1
XP_047291847.1
XP_047291848.1
XP_047291849.1
XP_047291850.1
XP_054171870.1
XP_054171871.1
XP_054171872.1
XP_054171873.1
XP_054171874.1
XP_054171875.1
XP_054171876.1
XP_054171877.1
XP_054171878.1
XP_054171879.1
XP_054171880.1
XP_054171881.1
XP_054171882.1
XP_054171883.1
XP_054171884.1
XP_054171885.1
XP_054171886.1
XP_054171887.1
XP_054185260.1
XP_054185261.1
XP_054185262.1
XP_054185263.1
XP_054185264.1
XP_054185265.1
XP_054185266.1
XP_054185267.1
XP_054185268.1
XP_054185269.1
XP_054185270.1
XP_054185271.1
XP_054185272.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023295.2 RefSeqGene

    Range
    4976..326820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_198834.3 → NP_942131.1  acetyl-CoA carboxylase 1 isoform 1

    See identical proteins and their annotated locations for NP_942131.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB371587, AC243654, AY315625, BC041598, CF454424
    Consensus CDS
    CCDS42302.1
    UniProtKB/TrEMBL
    A2NX49
    Related
    ENSP00000483300.1, ENST00000616317.5
    Conserved Domains (8) summary
    COG0439
    Location:155 → 657
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:708 → 855
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:155 → 274
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:790 → 855
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1706 → 2254
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:544 → 651
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:857 → 1606
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:316 → 507
    ATP-grasp_4; ATP-grasp domain

  2. NM_198836.3 → NP_942133.1  acetyl-CoA carboxylase 1 isoform 2

    See identical proteins and their annotated locations for NP_942133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon, and uses a downstream start codon, as compared to variant (1). The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB371587, AY315621, BC041598
    Consensus CDS
    CCDS11317.1
    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
    UniProtKB/TrEMBL
    A2NX49
    Related
    ENSP00000478547.1, ENST00000614428.4
    Conserved Domains (5) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:754 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1569
    ACC_central; Acetyl-CoA carboxylase, central region

  3. NM_198837.2 → NP_942134.1  acetyl-CoA carboxylase 1 isoform 3

    See identical proteins and their annotated locations for NP_942134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has a shorter and alternate 5' sequence, as compared to variant 1. The resulting isoform (3) has a distinct and shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AY315620, AY315627, BC031485, BC041598, U19822
    Consensus CDS
    CCDS11318.1
    UniProtKB/TrEMBL
    A2NX49
    Related
    ENSP00000482269.1, ENST00000612895.4
    Conserved Domains (8) summary
    COG0439
    Location:60 → 562
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:613 → 760
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:60 → 179
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:695 → 760
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1611 → 2159
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:449 → 556
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:762 → 1511
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:221 → 412
    ATP-grasp_4; ATP-grasp domain

  4. NM_198838.2 → NP_942135.1  acetyl-CoA carboxylase 1 isoform 4

    See identical proteins and their annotated locations for NP_942135.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a shorter and alternate 5' sequence and uses a downstream start codon, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AY315619, AY315627, BC031485, BC041598, U19822
    Consensus CDS
    CCDS42303.1
    UniProtKB/TrEMBL
    A2NX49
    Related
    ENSP00000482368.1, ENST00000617649.4
    Conserved Domains (8) summary
    COG0439
    Location:40 → 542
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:593 → 740
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:40 → 159
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:675 → 740
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1591 → 2139
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:429 → 536
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:742 → 1491
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:201 → 392
    ATP-grasp_4; ATP-grasp domain

  5. NM_198839.3 → NP_942136.1  acetyl-CoA carboxylase 1 isoform 2

    See identical proteins and their annotated locations for NP_942136.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is the longest transcript, which has several additional exons in the 5' region, as compared to variant 1. It uses a downstream start codon and the resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB371587, AC243654, AY315623, BC041598, CF454424
    Consensus CDS
    CCDS11317.1
    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
    UniProtKB/TrEMBL
    A2NX49
    Conserved Domains (5) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:754 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1569
    ACC_central; Acetyl-CoA carboxylase, central region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    37084992..37406836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524701.2 → XP_011523003.1  acetyl-CoA carboxylase 1 isoform X2

    See identical proteins and their annotated locations for XP_011523003.1

    UniProtKB/TrEMBL
    A2NX49
    Conserved Domains (8) summary
    COG0439
    Location:125 → 627
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:678 → 825
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:125 → 244
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:760 → 825
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1676 → 2224
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:514 → 621
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:827 → 1576
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:286 → 477
    ATP-grasp_4; ATP-grasp domain

  2. XM_006721853.2 → XP_006721916.1  acetyl-CoA carboxylase 1 isoform X1

    UniProtKB/TrEMBL
    A2NX49
    Conserved Domains (8) summary
    COG0439
    Location:155 → 657
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:708 → 855
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:155 → 274
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:790 → 855
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1698 → 2246
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:544 → 651
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:857 → 1598
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:316 → 507
    ATP-grasp_4; ATP-grasp domain

  3. XM_047435882.1 → XP_047291838.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3

  4. XM_047435883.1 → XP_047291839.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3

  5. XM_047435881.1 → XP_047291837.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3

  6. XM_047435879.1 → XP_047291835.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3

  7. XM_047435880.1 → XP_047291836.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3

  8. XM_047435878.1 → XP_047291834.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3

  9. XM_047435892.1 → XP_047291848.1  acetyl-CoA carboxylase 1 isoform X7

  10. XM_005257267.6 → XP_005257324.1  acetyl-CoA carboxylase 1 isoform X6

    See identical proteins and their annotated locations for XP_005257324.1

    UniProtKB/TrEMBL
    A2NX49
    Conserved Domains (8) summary
    COG0439
    Location:40 → 542
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:593 → 740
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:40 → 159
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:675 → 740
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1591 → 2139
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:429 → 536
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:742 → 1491
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:201 → 392
    ATP-grasp_4; ATP-grasp domain

  11. XM_047435891.1 → XP_047291847.1  acetyl-CoA carboxylase 1 isoform X7

  12. XM_011524704.3 → XP_011523006.1  acetyl-CoA carboxylase 1 isoform X6

    See identical proteins and their annotated locations for XP_011523006.1

    UniProtKB/TrEMBL
    A2NX49
    Conserved Domains (8) summary
    COG0439
    Location:40 → 542
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:593 → 740
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:40 → 159
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:675 → 740
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1591 → 2139
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:429 → 536
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:742 → 1491
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:201 → 392
    ATP-grasp_4; ATP-grasp domain

  13. XM_047435884.1 → XP_047291840.1  acetyl-CoA carboxylase 1 isoform X4

  14. XM_047435893.1 → XP_047291849.1  acetyl-CoA carboxylase 1 isoform X7

  15. XM_047435890.1 → XP_047291846.1  acetyl-CoA carboxylase 1 isoform X6

  16. XM_047435885.1 → XP_047291841.1  acetyl-CoA carboxylase 1 isoform X4

  17. XM_011524703.1 → XP_011523005.1  acetyl-CoA carboxylase 1 isoform X3

    See identical proteins and their annotated locations for XP_011523005.1

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
    UniProtKB/TrEMBL
    A2NX49
    Conserved Domains (5) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:754 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1569
    ACC_central; Acetyl-CoA carboxylase, central region

  18. XM_047435888.1 → XP_047291844.1  acetyl-CoA carboxylase 1 isoform X5

  19. XM_047435886.1 → XP_047291842.1  acetyl-CoA carboxylase 1 isoform X8

  20. XM_047435889.1 → XP_047291845.1  acetyl-CoA carboxylase 1 isoform X5

  21. XM_047435894.1 → XP_047291850.1  acetyl-CoA carboxylase 1 isoform X9

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1320992..1645992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329294.1 → XP_054185269.1  acetyl-CoA carboxylase 1 isoform X6

  2. XM_054329286.1 → XP_054185261.1  acetyl-CoA carboxylase 1 isoform X2

  3. XM_054329285.1 → XP_054185260.1  acetyl-CoA carboxylase 1 isoform X1

  4. XM_054329287.1 → XP_054185262.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3

  5. XM_054329296.1 → XP_054185271.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3

  6. XM_054329288.1 → XP_054185263.1  acetyl-CoA carboxylase 1 isoform X4

  7. XM_054329295.1 → XP_054185270.1  acetyl-CoA carboxylase 1 isoform X7

  8. XM_054329292.1 → XP_054185267.1  acetyl-CoA carboxylase 1 isoform X6

  9. XM_054329293.1 → XP_054185268.1  acetyl-CoA carboxylase 1 isoform X6

  10. XM_054329289.1 → XP_054185264.1  acetyl-CoA carboxylase 1 isoform X4

  11. XM_054329291.1 → XP_054185266.1  acetyl-CoA carboxylase 1 isoform X5

  12. XM_054329290.1 → XP_054185265.1  acetyl-CoA carboxylase 1 isoform X5

  13. XM_054329297.1 → XP_054185272.1  acetyl-CoA carboxylase 1 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    38071975..38396996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315907.1 → XP_054171882.1  acetyl-CoA carboxylase 1 isoform X6

  2. XM_054315898.1 → XP_054171873.1  acetyl-CoA carboxylase 1 isoform X2

  3. XM_054315897.1 → XP_054171872.1  acetyl-CoA carboxylase 1 isoform X1

  4. XM_054315896.1 → XP_054171871.1  acetyl-CoA carboxylase 1 isoform X12

  5. XM_054315895.1 → XP_054171870.1  acetyl-CoA carboxylase 1 isoform X11

  6. XM_054315899.1 → XP_054171874.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3

  7. XM_054315911.1 → XP_054171886.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3

  8. XM_054315901.1 → XP_054171876.1  acetyl-CoA carboxylase 1 isoform X4

  9. XM_054315910.1 → XP_054171885.1  acetyl-CoA carboxylase 1 isoform X7

  10. XM_054315908.1 → XP_054171883.1  acetyl-CoA carboxylase 1 isoform X7

  11. XM_054315904.1 → XP_054171879.1  acetyl-CoA carboxylase 1 isoform X6

  12. XM_054315909.1 → XP_054171884.1  acetyl-CoA carboxylase 1 isoform X7

  13. XM_054315905.1 → XP_054171880.1  acetyl-CoA carboxylase 1 isoform X6

  14. XM_054315900.1 → XP_054171875.1  acetyl-CoA carboxylase 1 isoform X4

  15. XM_054315906.1 → XP_054171881.1  acetyl-CoA carboxylase 1 isoform X6

  16. XM_054315903.1 → XP_054171878.1  acetyl-CoA carboxylase 1 isoform X5

  17. XM_054315902.1 → XP_054171877.1  acetyl-CoA carboxylase 1 isoform X5

  18. XM_054315912.1 → XP_054171887.1  acetyl-CoA carboxylase 1 isoform X13

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_000664.3: Suppressed sequence

    Description
    NM_000664.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_198835.1: Suppressed sequence

    Description
    NM_198835.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13085.2 GenPept UniProtKB/Swiss-Prot:Q13085

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