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elav embryonic lethal abnormal vision [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31000, updated on 27-Mar-2024

Summary

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Official Symbol
elavprovided by FlyBase
Official Full Name
embryonic lethal abnormal visionprovided by FlyBase
Primary source
FLYBASE:FBgn0260400
Locus tag
Dmel_CG4262
See related
AllianceGenome:FB:FBgn0260400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
44C11; 9F8A9; CG4262; dHuR; Dmel\CG4262; EC7; EG:65F1.2; Elav; ElaV; ELav; ELAV; elav-1; elav-2; elav-3; Elav-9F8A9; END1-2; fliJ; l(1)1Be; l(1)EC7; l(1)G0031; l(1)G0319; weg
Summary
Enables poly(U) RNA binding activity. Involved in central nervous system development and negative regulation of mRNA 3'-end processing. Located in Cajal body. Is expressed in several structures, including eye-antennal disc; nervous system; photoreceptor; procephalic segment; and terminalia. Orthologous to human ELAVL3 (ELAV like RNA binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See elav in Genome Data Viewer
Location:
1B7-1B8; 1-0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (509235..523226, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (403268..417259, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44891 Neighboring gene antisense RNA:CR44892 Neighboring gene silver Neighboring gene elav noncoding regulatory RNA Neighboring gene arginase Neighboring gene uncharacterized protein Neighboring gene beta amyloid protein precursor-like Neighboring gene mir-4960 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The biological characters of Bmelav-like genes in the development of Bombyx mori. Sun X, et al. Insect Mol Biol, 2021 Feb. PMID 32940384
  2. Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer's Disease. Pham HM, et al. Biomed Res Int, 2018. PMID 30228985, Free PMC Article
  3. Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4. Yi J, et al. PLoS One, 2013. PMID 23382971, Free PMC Article
  4. Drosophila melanogaster: a new model to study cisplatin-induced neurotoxicity. Podratz JL, et al. Neurobiol Dis, 2011 Aug. PMID 21514385, Free PMC Article
  5. Design and utility of temperature-sensitive Gal4 mutants for conditional gene expression in Drosophila. Mondal K, et al. Fly (Austin), 2007 Sep-Oct. PMID 18836309

See all (1281) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.
    Title: Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.
  2. The biological characters of Bmelav-like genes in the development of Bombyx mori.
    Title: The biological characters of Bmelav-like genes in the development of Bombyx mori.
  3. ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing.
    Title: ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing.
  4. ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
    Title: ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
  5. The Dscam1 long 3' UTR was found to be required for correct Elav-mediated skipping of exon 19. Elav thus co-regulates APA and alternative splicing to generate specific Dscam1 transcripts that are essential for neural development.
    Title: Elav-Mediated Exon Skipping and Alternative Polyadenylation of the Dscam1 Gene Are Required for Axon Outgrowth.
  6. Ubiquitous Elav has regulatory capacity, since derepressed Elav can stabilize an Elav-responsive sensor. Repression of Elav in non-neural territories is crucial as misexpression here has profoundly adverse consequences.
    Title: Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues.
  7. Paused Pol II promotes recruitment of ELAV to extended genes in Drosophila.
    Title: ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system.
  8. The modulation of Hox RNA processing by ELAV serves to adapt the morphogenesis of the CNS to axial level by regulating Hox expression and consequently activating local programmes of neural differentiation.
    Title: The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system.
  9. Reducing Elav levels significantly suppressed the worniu mutant phenotype.
    Title: The Snail family member Worniu is continuously required in neuroblasts to prevent Elav-induced premature differentiation.
  10. RNA immunoprecipitation assays suggest that ELAV directly binds the proximal polyadenylation signals of many target mRNAs
    Title: ELAV mediates 3' UTR extension in the Drosophila nervous system.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables mRNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in germ cell development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of mRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of oskar mRNA translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
embryonic lethal abnormal vision
Names
CG4262-PA
CG4262-PB
CG4262-PC
CG4262-PD
elav
elav-PA
elav-PB
elav-PC
elav-PD
embryonic lethal abnormal visual system
embryonic lethal, abnormal vision
embryonically lethal abnormal vision
weniger

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    509235..523226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258518.3 → NP_001245447.1  embryonic lethal abnormal vision, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245447.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P16914, Q7K7L9, Q9V3F6
    UniProtKB/TrEMBL
    M9NFP7
    Conserved Domains (1) summary
    TIGR01661
    Location:146 → 483
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. NM_001014713.4 → NP_001014713.1  embryonic lethal abnormal vision, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014713.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P16914
    Conserved Domains (1) summary
    TIGR01661
    Location:142 → 479
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. NM_001144670.2 → NP_001138142.1  embryonic lethal abnormal vision, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138142.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P16914
    Conserved Domains (1) summary
    TIGR01661
    Location:142 → 479
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  4. NM_080294.5 → NP_525033.1  embryonic lethal abnormal vision, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525033.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P16914, Q7K7L9, Q9V3F6
    UniProtKB/TrEMBL
    M9NFP7
    Related
    FBpp0070086
    Conserved Domains (1) summary
    TIGR01661
    Location:146 → 483
    ELAV_HUD_SF; ELAV/HuD family splicing factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NFP7 M9NFP7
P16914.1 P16914

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