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Otulinl OTU deubiquitinase with linear linkage specificity like [ Rattus norvegicus (Norway rat) ]

Gene ID: 310190, updated on 11-Apr-2024

Summary

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Official Symbol
Otulinlprovided by RGD
Official Full Name
OTU deubiquitinase with linear linkage specificity likeprovided by RGD
Primary source
RGD:1563205
See related
Ensembl:ENSRNOG00000012109 AllianceGenome:RGD:1563205
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam105a
Summary
Predicted to be located in cytoplasm. Predicted to be extrinsic component of endoplasmic reticulum membrane. Predicted to colocalize with nuclear envelope. Orthologous to human OTULINL (OTU deubiquitinase with linear linkage specificity like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 364.0), Spleen (RPKM 166.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (80136411..80164290, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (78405994..78433860, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (80383642..80408672, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100754 Neighboring gene ANKH inorganic pyrophosphate transport regulator Neighboring gene OTU deubiquitinase with linear linkage specificity Neighboring gene trio Rho guanine nucleotide exchange factor Neighboring gene uncharacterized LOC134485866 Neighboring gene ribosomal protein L19, pseudogene 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane. Ceccarelli DF, et al. Structure, 2019 Jun 4. PMID 31056421, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124675

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables ubiquitin-like protein peptidase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables ubiquitin-like protein peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic side of endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
inactive ubiquitin thioesterase OTULINL
Names
family with sequence similarity 105, member A
inactive ubiquitin thioesterase FAM105A
protein FAM105A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037648.1 → NP_001032737.1  inactive ubiquitin thioesterase OTULINL

    See identical proteins and their annotated locations for NP_001032737.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107649
    UniProtKB/Swiss-Prot
    Q3B7D8
    UniProtKB/TrEMBL
    A0A8I6AC08
    Related
    ENSRNOP00000095953.1, ENSRNOT00000096292.1
    Conserved Domains (1) summary
    pfam16218
    Location:86 → 352
    Peptidase_C101; Peptidase family C101

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    80136411..80164290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102220.2 → XP_038958148.1  inactive ubiquitin thioesterase OTULINL isoform X2

    UniProtKB/TrEMBL
    A0A8I6AC08
    Conserved Domains (1) summary
    pfam16218
    Location:86 → 311
    Peptidase_C101; Peptidase family C101

  2. XM_039102221.2 → XP_038958149.1  inactive ubiquitin thioesterase OTULINL isoform X3

    UniProtKB/TrEMBL
    A0A8I6AC08
    Related
    ENSRNOP00000090546.1
    Conserved Domains (1) summary
    pfam16218
    Location:41 → 307
    Peptidase_C101; Peptidase family C101

  3. XM_063281751.1 → XP_063137821.1  inactive ubiquitin thioesterase OTULINL isoform X4

  4. XM_039102219.2 → XP_038958147.1  inactive ubiquitin thioesterase OTULINL isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7F3, A0A8I6AC08
    Related
    ENSRNOP00000089086.1
    Conserved Domains (1) summary
    pfam16218
    Location:79 → 345
    Peptidase_C101; Peptidase family C101

  5. XM_039102222.2 → XP_038958150.1  inactive ubiquitin thioesterase OTULINL isoform X5

    Conserved Domains (1) summary
    pfam16218
    Location:23 → 214
    Peptidase_C101; Peptidase family C101

  6. XM_039102224.2 → XP_038958152.1  inactive ubiquitin thioesterase OTULINL isoform X6

    Conserved Domains (1) summary
    pfam16218
    Location:86 → 163
    Peptidase_C101; Peptidase family C101

  7. XM_039102223.2 → XP_038958151.1  inactive ubiquitin thioesterase OTULINL isoform X6

    Conserved Domains (1) summary
    pfam16218
    Location:86 → 163
    Peptidase_C101; Peptidase family C101
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3B7D8.1 GenPept UniProtKB/Swiss-Prot:Q3B7D8

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