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Igsf10 immunoglobulin superfamily, member 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310448, updated on 13-Apr-2024

Summary

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Official Symbol
Igsf10provided by RGD
Official Full Name
immunoglobulin superfamily, member 10provided by RGD
Primary source
RGD:735030
See related
Ensembl:ENSRNOG00000013917 AllianceGenome:RGD:735030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in tissue regeneration. Acts upstream of or within ossification. Predicted to be active in extracellular region. Orthologous to human IGSF10 (immunoglobulin superfamily member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 247.1), Lung (RPKM 94.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q26
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (145725868..145754850, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (143575710..143605044, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (149535199..149564180, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene purinergic receptor P2Y13 Neighboring gene purinergic receptor P2Y12 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene arylacetamide deacetylase-like 2 like Neighboring gene AADACL2 family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CMF608-a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells. Segev O, et al. Bone, 2004 Feb. PMID 14962803
  2. IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. Howard SR, et al. EMBO Mol Med, 2016 Jun. PMID 27137492, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ossification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tissue regeneration IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily member 10
Names
CMF608
bone specific CMF608
calvaria mechanical force protein 608

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198768.3 → NP_942063.2  immunoglobulin superfamily member 10 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q6WRH9
    UniProtKB/TrEMBL
    A6JVK7, G3V7S1
    Related
    ENSRNOP00000018629.4, ENSRNOT00000018628.6
    Conserved Domains (11) summary
    TIGR00864
    Location:192 → 273
    PCC; polycystin cation channel protein
    smart00013
    Location:28 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:219 → 243
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2128 → 2202
    IG; Immunoglobulin
    smart00410
    Location:2027 → 2110
    IG_like; Immunoglobulin like
    sd00033
    Location:39 → 58
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:1139 → 1450
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:81 → 141
    LRR_8; Leucine rich repeat
    pfam13927
    Location:2405 → 2484
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1930 → 1940
    Ig; putative Ig strand B [structural motif]
    cl11960
    Location:1640 → 1713
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    145725868..145754850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590862.3 → XP_017446351.1  immunoglobulin superfamily member 10 isoform X2

    UniProtKB/Swiss-Prot
    Q6WRH9
    UniProtKB/TrEMBL
    A6JVK7, G3V7S1
    Conserved Domains (11) summary
    TIGR00864
    Location:192 → 273
    PCC; polycystin cation channel protein
    smart00013
    Location:28 → 60
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:219 → 243
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2128 → 2202
    IG; Immunoglobulin
    smart00410
    Location:2027 → 2110
    IG_like; Immunoglobulin like
    sd00033
    Location:39 → 58
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:1139 → 1450
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:81 → 141
    LRR_8; Leucine rich repeat
    pfam13927
    Location:2405 → 2484
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1930 → 1940
    Ig; putative Ig strand B [structural motif]
    cl11960
    Location:1640 → 1713
    Ig; Immunoglobulin domain

  2. XM_039102267.2 → XP_038958195.1  immunoglobulin superfamily member 10 isoform X1

    UniProtKB/Swiss-Prot
    Q6WRH9
    Conserved Domains (11) summary
    TIGR00864
    Location:242 → 323
    PCC; polycystin cation channel protein
    smart00013
    Location:78 → 110
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:269 → 293
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2178 → 2252
    IG; Immunoglobulin
    smart00410
    Location:2077 → 2160
    IG_like; Immunoglobulin like
    sd00033
    Location:89 → 108
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:1189 → 1500
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:131 → 191
    LRR_8; Leucine rich repeat
    pfam13927
    Location:2455 → 2534
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1980 → 1990
    Ig; putative Ig strand B [structural motif]
    cl11960
    Location:1690 → 1763
    Ig; Immunoglobulin domain

  3. XM_039102266.2 → XP_038958194.1  immunoglobulin superfamily member 10 isoform X1

    UniProtKB/Swiss-Prot
    Q6WRH9
    Conserved Domains (11) summary
    TIGR00864
    Location:242 → 323
    PCC; polycystin cation channel protein
    smart00013
    Location:78 → 110
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:269 → 293
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2178 → 2252
    IG; Immunoglobulin
    smart00410
    Location:2077 → 2160
    IG_like; Immunoglobulin like
    sd00033
    Location:89 → 108
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:1189 → 1500
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:131 → 191
    LRR_8; Leucine rich repeat
    pfam13927
    Location:2455 → 2534
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1980 → 1990
    Ig; putative Ig strand B [structural motif]
    cl11960
    Location:1690 → 1763
    Ig; Immunoglobulin domain

  4. XM_039102265.2 → XP_038958193.1  immunoglobulin superfamily member 10 isoform X1

    UniProtKB/Swiss-Prot
    Q6WRH9
    Conserved Domains (11) summary
    TIGR00864
    Location:242 → 323
    PCC; polycystin cation channel protein
    smart00013
    Location:78 → 110
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:269 → 293
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2178 → 2252
    IG; Immunoglobulin
    smart00410
    Location:2077 → 2160
    IG_like; Immunoglobulin like
    sd00033
    Location:89 → 108
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:1189 → 1500
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:131 → 191
    LRR_8; Leucine rich repeat
    pfam13927
    Location:2455 → 2534
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1980 → 1990
    Ig; putative Ig strand B [structural motif]
    cl11960
    Location:1690 → 1763
    Ig; Immunoglobulin domain

  5. XM_039102264.2 → XP_038958192.1  immunoglobulin superfamily member 10 isoform X1

    UniProtKB/Swiss-Prot
    Q6WRH9
    Conserved Domains (11) summary
    TIGR00864
    Location:242 → 323
    PCC; polycystin cation channel protein
    smart00013
    Location:78 → 110
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:269 → 293
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2178 → 2252
    IG; Immunoglobulin
    smart00410
    Location:2077 → 2160
    IG_like; Immunoglobulin like
    sd00033
    Location:89 → 108
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:1189 → 1500
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:131 → 191
    LRR_8; Leucine rich repeat
    pfam13927
    Location:2455 → 2534
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1980 → 1990
    Ig; putative Ig strand B [structural motif]
    cl11960
    Location:1690 → 1763
    Ig; Immunoglobulin domain

  6. XM_039102268.2 → XP_038958196.1  immunoglobulin superfamily member 10 isoform X3

    UniProtKB/Swiss-Prot
    Q6WRH9
    Conserved Domains (6) summary
    smart00409
    Location:357 → 437
    IG; Immunoglobulin
    smart00410
    Location:1903 → 1977
    IG_like; Immunoglobulin like
    pfam05109
    Location:914 → 1225
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13927
    Location:2180 → 2259
    Ig_3; Immunoglobulin domain
    cd00096
    Location:2190 → 2194
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:1415 → 1488
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6WRH9.1 GenPept UniProtKB/Swiss-Prot:Q6WRH9

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