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B3galnt1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) [ Rattus norvegicus (Norway rat) ]

Gene ID: 310508, updated on 11-Apr-2024

Summary

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Official Symbol
B3galnt1provided by RGD
Official Full Name
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)provided by RGD
Primary source
RGD:1304797
See related
Ensembl:ENSRNOG00000012019 AllianceGenome:RGD:1304797
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
B3galt3
Summary
Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to act upstream of or within oligosaccharide biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Orthologous to human B3GALNT1 (beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 141.1), Lung (RPKM 114.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (156157234..156187037, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (153847297..153877371, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (166226736..166255978, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3b, pseudogene 2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1L Neighboring gene ubiquitin-like modifier activating enzyme 3, pseudogene 1 Neighboring gene uncharacterized LOC134485628 Neighboring gene ATPase H+ transporting V1 subunit A, pseudogene 1 Neighboring gene phosphoserine aminotransferase 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes. Hennet T, et al. J Biol Chem, 1998 Jan 2. PMID 9417047
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
Names
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3
UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1
UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
b3Gal-T3
beta-1,3-GalNAc-T1
beta-1,3-GalTase 3
beta-1,3-galactosyltransferase 3
beta-3-GalNAc-T1
beta-3-Gx-T3
beta3Gal-T3
beta3GalT3
galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
globoside synthase
NP_001013176.1
XP_017446356.1
XP_017446358.1
XP_017446359.1
XP_038958217.1
XP_038958218.1
XP_038958219.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013158.2 → NP_001013176.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_001013176.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q6AY39
    UniProtKB/TrEMBL
    A6J5N4
    Related
    ENSRNOP00000090410.1, ENSRNOT00000099448.1
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 285
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    156157234..156187037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590869.3 → XP_017446358.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY39
    UniProtKB/TrEMBL
    A6J5N4
    Related
    ENSRNOP00000079916.1
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 285
    Galactosyl_T; Galactosyltransferase

  2. XM_017590870.3 → XP_017446359.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY39
    UniProtKB/TrEMBL
    A6J5N4
    Related
    ENSRNOP00000090178.1
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 285
    Galactosyl_T; Galactosyltransferase

  3. XM_017590867.3 → XP_017446356.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY39
    UniProtKB/TrEMBL
    A6J5N4
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 285
    Galactosyl_T; Galactosyltransferase

  4. XM_039102289.2 → XP_038958217.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY39
    UniProtKB/TrEMBL
    A6J5N4
    Related
    ENSRNOP00000092519.1
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 285
    Galactosyl_T; Galactosyltransferase

  5. XM_039102291.2 → XP_038958219.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY39
    UniProtKB/TrEMBL
    A6J5N4
    Related
    ENSRNOP00000091655.1
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 285
    Galactosyl_T; Galactosyltransferase

  6. XM_039102290.2 → XP_038958218.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY39
    UniProtKB/TrEMBL
    A6J5N4
    Related
    ENSRNOP00000079867.1
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 285
    Galactosyl_T; Galactosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY39.1 GenPept UniProtKB/Swiss-Prot:Q6AY39

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