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Inka2 inka box actin regulator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310764, updated on 13-Apr-2024

Summary

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Official Symbol
Inka2provided by RGD
Official Full Name
inka box actin regulator 2provided by RGD
Primary source
RGD:1306526
See related
Ensembl:ENSRNOG00000015691 AllianceGenome:RGD:1306526
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam212b; RGD1306526
Summary
Predicted to enable protein kinase binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be involved in negative regulation of catalytic activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human INKA2 (inka box actin regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 186.9), Brain (RPKM 130.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (195873617..195888983)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (193185275..193200643)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (208170652..208187088)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily D member 3 Neighboring gene uncharacterized LOC134485946 Neighboring gene DEAD-box helicase 20 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene RAS-related protein 1a like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1. Baskaran Y, et al. Nat Commun, 2015 Nov 26. PMID 26607847, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PAK4-inhibitor INKA2
Names
family with sequence similarity 212, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107713.2 → NP_001101183.1  PAK4-inhibitor INKA2

    See identical proteins and their annotated locations for NP_001101183.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6K3R7, A6K3R8, D4ACF3
    Related
    ENSRNOP00000021001.4, ENSRNOT00000021001.6
    Conserved Domains (1) summary
    pfam15342
    Location:138 → 177
    FAM212; FAM212 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    195873617..195888983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233088.5 → XP_006233150.1  PAK4-inhibitor INKA2 isoform X1

    UniProtKB/TrEMBL
    A6K3R8
    Conserved Domains (1) summary
    pfam15342
    Location:149 → 188
    FAM212; FAM212 family
Nucleotide Protein Strain
Heading Accession and Version

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