Slc30a7 solute carrier family 30 member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc30a7provided by RGD
Official Full Name: solute carrier family 30 member 7provided by RGD
Primary source: RGD:1307873
See related: Ensembl:ENSRNOG00000013912 AllianceGenome:RGD:1307873
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cation transmembrane transporter activity. Predicted to be involved in cation transmembrane transport. Predicted to act upstream of or within sequestering of zinc ion and zinc ion transport. Predicted to be located in cytoplasmic vesicle and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Orthologous to human SLC30A7 (solute carrier family 30 member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 108.7), Liver (RPKM 107.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (206544800..206607087, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (203855484..203922155, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (218888431..218951030, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Slc30a7/ZnT7 increases the mitochondrial matrix levels of labile Zn[2+] and modifies histone modification in hyperinsulinemic cardiomyoblasts.
Title: Overexpression of Slc30a7/ZnT7 increases the mitochondrial matrix levels of labile Zn(2+) and modifies histone modification in hyperinsulinemic cardiomyoblasts.
Overall, this study provides an important description about the role of ZIP7 and ZnT7, localized to both mitochondria and sarco(endo)plasmic reticulum and contribute to cellular Zn(2+)-muffling between cellular-compartments in hyperglycemia or hypertrophic cardiomyocytes via affecting sarco(endo)plasmic reticulum-mitochondria coupling.
Title: Zn(2+)-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes.
evidence that ZnT7 has a protective effect over epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells in diabetic nephropathy and suggests that the inhibition of HG-induced EMT may be achieved through the MAPK/ERK and TGF-beta/Smad pathways.
Title: Protective Effect of Znt7 on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells.
Markedly increased mRNA and protein levels of ZIP7 were observed in ventricular cardiomyocytes from diabetic rats or high-glucose-treated H9c2 cells while ZnT7 expression was low.
Title: Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn(2+) Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart.
The recurrent seizures plus normal diet group showed worse performances in neurological reflex tests and reduced latencies to myoclonic seizures induced by penicillin compared with the control, which was concomitant with altered expressions of ZnT-7, MT-1, MT-2, and ZIP7.
Title: Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions.
Data suggest that the ZnT7 (Slc30A7) may account for the inhibition of high glucose (HG)-induced epithelial-to-mesenchymal transition (EMT) in peritoneal mesothelial cells (PMCs).
Title: Zinc transporter 7 induced by high glucose attenuates epithelial-to-mesenchymal transition of peritoneal mesothelial cells.

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General gene information

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Markers

Slc30a7 (e-PCR), detects polymorphism
- UniSTS:547079

RH134894 (e-PCR)
- UniSTS:218172

D2Rat260 (e-PCR), detects polymorphism
- UniSTS:227401

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into Golgi lumen	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion import into Golgi lumen	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into Golgi lumen	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within zinc ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in Golgi cis cisterna membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi cis cisterna membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc transporter 7

Names: solute carrier family 30 (zinc transporter), member 7; znT-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.