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Gstcd glutathione S-transferase, C-terminal domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 310855, updated on 13-Apr-2024

Summary

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Symbol
Gstcdprovided by RGD
Full Name
glutathione S-transferase, C-terminal domain containingprovided by RGD
Primary source
RGD:1311822
See related
Ensembl:ENSRNOG00000011669 AllianceGenome:RGD:1311822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311822
Summary
Predicted to be active in cytoplasm. Orthologous to human GSTCD (glutathione S-transferase C-terminal domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 42.9), Thymus (RPKM 30.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gstcd in Genome Data Viewer
Location:
2q43
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (224173764..224268743, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (221499732..221591888, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (238109758..238253326, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nephronectin Neighboring gene MTOR associated protein, eak-7 homolog, pseudogene 1 Neighboring gene uncharacterized LOC102548236 Neighboring gene integrator complex subunit 12 Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene uncharacterized LOC102546359 Neighboring gene inorganic pyrophosphatase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GSTCD and INTS12 regulation and expression in the human lung. Obeidat M, et al. PLoS One, 2013. PMID 24058608, Free PMC Article
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione S-transferase C-terminal domain-containing protein
Names
glutathione S-transferase C-terminal domain-containing protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395011.1 → NP_001381940.1  glutathione S-transferase C-terminal domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2K635, A0A8I6AB77, A6HVU2, A6HVU3
    Conserved Domains (2) summary
    cl02776
    Location:235 → 326
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:420 → 538
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001395012.1 → NP_001381941.1  glutathione S-transferase C-terminal domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2K635, A0A8I6AB77, A6HVU2, A6HVU3
    Conserved Domains (2) summary
    cl02776
    Location:235 → 326
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:420 → 538
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_001395013.1 → NP_001381942.1  glutathione S-transferase C-terminal domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2K635, A0A8I6AB77, A6HVU2, A6HVU3
    Conserved Domains (2) summary
    cl02776
    Location:235 → 326
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:420 → 538
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    224173764..224268743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281959.1 → XP_063138029.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6AB77, A6HVU2

  2. XM_039102457.2 → XP_038958385.1  glutathione S-transferase C-terminal domain-containing protein isoform X2

    UniProtKB/TrEMBL
    A0A0G2K635, A6HVU3, D4A322, D4AC90
    Related
    ENSRNOP00000035041.4
    Conserved Domains (2) summary
    cl02776
    Location:235 → 326
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:420 → 538
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_063281960.1 → XP_063138030.1  glutathione S-transferase C-terminal domain-containing protein isoform X2

    UniProtKB/TrEMBL
    D4A322, D4AC90

  4. XM_063281958.1 → XP_063138028.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6AB77, A6HVU2

  5. XM_039102454.2 → XP_038958382.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A0G2K635, A0A8I6AB77, A6HVU2, A6HVU3
    Related
    ENSRNOP00000088663.1
    Conserved Domains (2) summary
    cl02776
    Location:235 → 326
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:420 → 538
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  6. XM_063281962.1 → XP_063138032.1  glutathione S-transferase C-terminal domain-containing protein isoform X7

  7. XM_039102461.2 → XP_038958389.1  glutathione S-transferase C-terminal domain-containing protein isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:161 → 279
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  8. XM_039102458.2 → XP_038958386.1  glutathione S-transferase C-terminal domain-containing protein isoform X3

    UniProtKB/TrEMBL
    A0A0G2K635, A6HVU3
    Conserved Domains (2) summary
    cl02776
    Location:235 → 326
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:420 → 538
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  9. XM_039102460.2 → XP_038958388.1  glutathione S-transferase C-terminal domain-containing protein isoform X5

    UniProtKB/TrEMBL
    A6HVU4
    Conserved Domains (1) summary
    cl02776
    Location:235 → 326
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  10. XM_039102459.2 → XP_038958387.1  glutathione S-transferase C-terminal domain-containing protein isoform X4

    UniProtKB/TrEMBL
    A6HVU4
    Conserved Domains (1) summary
    cl02776
    Location:235 → 326
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107725.1: Suppressed sequence

    Description
    NM_001107725.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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