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Nostrin nitric oxide synthase trafficking [ Rattus norvegicus (Norway rat) ]

Gene ID: 311111, updated on 5-Mar-2024

Summary

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Official Symbol
Nostrinprovided by RGD
Official Full Name
nitric oxide synthase traffickingprovided by RGD
Primary source
RGD:727920
See related
Ensembl:ENSRNOG00000006611 AllianceGenome:RGD:727920
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity. Predicted to be involved in synaptic vesicle uncoating. Predicted to act upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Orthologous to human NOSTRIN (nitric oxide synthase trafficking). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 299.3), Liver (RPKM 71.6) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q21
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (74312594..74378852)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (53904746..53970995)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (55369282..55433840)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ceramide synthase 6 Neighboring gene uncharacterized LOC134486099 Neighboring gene Y box binding protein 1, pseudogene 9 Neighboring gene SPC25 component of NDC80 kinetochore complex Neighboring gene glucose-6-phosphatase catalytic subunit 2 Neighboring gene ATP binding cassette subfamily B member 11 Neighboring gene DNA mismatch repair protein Msh6-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mouse disabled 2 interacting protein 2 functions as a transcriptional repressor through direct binding onto its own promoter. Kim HW, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16171775
  2. Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats. Kirsch T, et al. Brain Res, 2001 Aug 10. PMID 11489260
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nostrin
Names
BM247
eNOS-trafficking inducer
nitric oxide synthase trafficker

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024260.1 → NP_001019431.1  nostrin

    See identical proteins and their annotated locations for NP_001019431.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088446
    UniProtKB/Swiss-Prot
    Q5I0D6, Q923J7
    UniProtKB/TrEMBL
    A0A8I6AC89
    Related
    ENSRNOP00000062066.2, ENSRNOT00000067161.4
    Conserved Domains (2) summary
    cd11823
    Location:443 → 494
    SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer
    cl12013
    Location:8 → 250
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    74312594..74378852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104842.2 → XP_038960770.1  nostrin isoform X1

    Conserved Domains (1) summary
    cl12013
    Location:8 → 211
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0D6.1 GenPept UniProtKB/Swiss-Prot:Q5I0D6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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