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Tspan18 tetraspanin 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311210, updated on 13-Apr-2024

Summary

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Official Symbol
Tspan18provided by RGD
Official Full Name
tetraspanin 18provided by RGD
Primary source
RGD:1560411
See related
Ensembl:ENSRNOG00000008758 AllianceGenome:RGD:1560411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560411
Summary
Predicted to be integral component of plasma membrane. Orthologous to human TSPAN18 (tetraspanin 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 116.1), Lung (RPKM 84.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (99615465..99755270, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (79160060..79299907, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (82097068..82236694, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal oxygenase 2, pseudogene 5 Neighboring gene tumor protein p53 inducible protein 11 Neighboring gene uncharacterized LOC120101602 Neighboring gene uncharacterized LOC134486408

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within calcium-ion regulated exocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin-18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107750.2 → NP_001101220.1  tetraspanin-18

    See identical proteins and their annotated locations for NP_001101220.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNI6, D4A3U2
    Conserved Domains (2) summary
    cd03156
    Location:105 → 218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 243
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    99615465..99755270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104912.2 → XP_038960840.1  tetraspanin-18 isoform X1

    UniProtKB/TrEMBL
    A6HNI6, D4A3U2
    Conserved Domains (2) summary
    cd03156
    Location:105 → 218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 243
    Tetraspannin; Tetraspanin family

  2. XM_006234574.5 → XP_006234636.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_006234636.1

    UniProtKB/TrEMBL
    A6HNI6, D4A3U2
    Related
    ENSRNOP00000011650.5
    Conserved Domains (2) summary
    cd03156
    Location:105 → 218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 243
    Tetraspannin; Tetraspanin family

  3. XM_039104911.2 → XP_038960839.1  tetraspanin-18 isoform X1

    UniProtKB/TrEMBL
    A6HNI6, D4A3U2
    Conserved Domains (2) summary
    cd03156
    Location:105 → 218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 243
    Tetraspannin; Tetraspanin family
Nucleotide Protein Strain
Heading Accession and Version

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