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Hr4 Hormone receptor 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31162, updated on 10-May-2024

Summary

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Official Symbol
Hr4provided by FlyBase
Official Full Name
Hormone receptor 4provided by FlyBase
Primary source
FLYBASE:FBgn0264562
Locus tag
Dmel_CG43934
See related
AllianceGenome:FB:FBgn0264562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null
Old locus tag
Dmel_CG16902; Dmel_CG3600; Dmel_CG42527
Summary
Enables nuclear receptor activity. Involved in several processes, including cellular response to hypoxia; negative regulation of ecdysone receptor-mediated signaling pathway; and regulation of pupariation. Located in cytoplasm and nucleus. Is expressed in border follicle cell; centripetal follicle cell; embryonic/larval fat body; prothoracic gland; and ring gland. Orthologous to human NR6A1 (nuclear receptor subfamily 6 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Hr4 in Genome Data Viewer
Location:
2B16-2C1; 1-0.5 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1941940..2007956)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1835973..1901989)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene long non-coding RNA:CR45478 Neighboring gene mir-2496 stem loop Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis. Weaver LN, et al. Development, 2021 Mar 9. PMID 33547134, Free PMC Article
  2. Early-late genes of the ecdysone cascade as models for transcriptional studies. Mazina MY, et al. Cell Cycle, 2015. PMID 26506480, Free PMC Article
  3. The Development of Reporter System for the Investigation of Molecular Mechanisms of Ecdysone Response. Mazina MY, et al. Dokl Biochem Biophys, 2019 Mar. PMID 31201635
  4. Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila. Kachaev ZM, et al. Cell Cycle, 2018. PMID 29995569, Free PMC Article
  5. Genomic mapping of binding regions for the Ecdysone receptor protein complex. Gauhar Z, et al. Genome Res, 2009 Jun. PMID 19237466, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis.
    Title: Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis.
  2. DHR3 and Hr4 gene expression is dose dependent, is completely controlled by the hormone titer and decreases within hours of 20-hydroxyecdysone withdrawal.
    Title: Early-late genes of the ecdysone cascade as models for transcriptional studies.
  3. Following the onset of zygotic gene expression, Slam and Nullo together stabilise the retracting metaphase furrow and Slam triggers invagination of the cleavage furrow.
    Title: Function and dynamics of slam in furrow formation in early Drosophila embryo.
  4. Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development
    Title: Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development.
  5. Results show that three direct targets of ECR/USP--hairy, vrille, and Hr4--are required for cellular differentiation in response to the hormone.
    Title: Genomic mapping of binding regions for the Ecdysone receptor protein complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nuclear receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of negative regulation of ecdysone receptor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of pupariation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hormone receptor 4
Names
CG43934-PC
CG43934-PD
CG43934-PE
CG43934-PF
CG43934-PG
CG43934-PH
CG43934-PI
CG43934-PJ
CG43934-PK
Hr4-PC
Hr4-PD
Hr4-PE
Hr4-PF
Hr4-PG
Hr4-PH
Hr4-PI
Hr4-PJ
Hr4-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1941940..2007956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272234.1 → NP_001259163.1  hormone receptor 4, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259163.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGA3
    Conserved Domains (2) summary
    cd06953
    Location:1580 → 1839
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07168
    Location:1237 → 1326
    NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

  2. NM_001272233.2 → NP_001259162.1  hormone receptor 4, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGA3
    Conserved Domains (2) summary
    cd06953
    Location:1580 → 1839
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07168
    Location:1237 → 1326
    NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

  3. NM_001272230.1 → NP_001259159.1  hormone receptor 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259159.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGH1
    Conserved Domains (2) summary
    cd06953
    Location:1266 → 1525
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07168
    Location:923 → 1012
    NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

  4. NM_001272227.1 → NP_001259156.1  hormone receptor 4, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259156.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDJ1
    Conserved Domains (2) summary
    cd06953
    Location:1723 → 1982
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07168
    Location:1380 → 1469
    NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

  5. NM_001272231.1 → NP_001259160.1  hormone receptor 4, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259160.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PIR5
    Conserved Domains (2) summary
    cd06953
    Location:1256 → 1515
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07168
    Location:913 → 1002
    NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

  6. NM_001272232.1 → NP_001259161.1  hormone receptor 4, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDJ5
    Conserved Domains (2) summary
    cd06953
    Location:1256 → 1515
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07168
    Location:913 → 1002
    NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

  7. NM_001038734.2 → NP_001033823.1  hormone receptor 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033823.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96836, Q56AW0, Q9W539
    Conserved Domains (2) summary
    cd06953
    Location:1256 → 1514
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07168
    Location:913 → 1002
    NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

  8. NM_001272229.1 → NP_001259158.1  hormone receptor 4, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259158.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGQ8
    Conserved Domains (2) summary
    cd06953
    Location:1580 → 1838
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07168
    Location:1237 → 1326
    NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

  9. NM_001272228.1 → NP_001259157.1  hormone receptor 4, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259157.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGA1
    Conserved Domains (2) summary
    cd06953
    Location:1349 → 1607
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07168
    Location:1006 → 1095
    NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDJ1 M9PDJ1
M9PDJ5 M9PDJ5
M9PGA1 M9PGA1
M9PGA3 M9PGA3
M9PGH1 M9PGH1
M9PGQ8 M9PGQ8
M9PIR5 M9PIR5
O96835 O96835
Q9W539.4 Q9W539

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