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Sulf2 sulfatase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311642, updated on 3-Apr-2024

Summary

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Official Symbol
Sulf2provided by RGD
Official Full Name
sulfatase 2provided by RGD
Primary source
RGD:1305078
See related
Ensembl:ENSRNOG00000006052 AllianceGenome:RGD:1305078
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-acetylglucosamine-6-sulfatase activity; arylsulfatase activity; and glycosaminoglycan binding activity. Predicted to be involved in several processes, including esophagus smooth muscle contraction; regulation of signal transduction; and skeletal system development. Predicted to act upstream of or within several processes, including liver regeneration; positive regulation of canonical Wnt signaling pathway; and regulation of hepatocyte proliferation. Predicted to be located in Golgi stack and extracellular space. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 147.3), Heart (RPKM 132.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q42
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (175241322..175323808, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (154822079..154904566, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (162791349..162872984, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909912 Neighboring gene nuclear receptor coactivator 3 Neighboring gene uncharacterized LOC120101930 Neighboring gene uncharacterized LOC134486206 Neighboring gene uncharacterized LOC120101786 Neighboring gene uncharacterized LOC108350523 Neighboring gene uncharacterized LOC134486477

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proteolytic cleavage of the rat heparan sulfate 6-O-endosulfatase SulfFP2 by furin-type proprotein convertases. Nagamine S, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19900405
  2. Expression of a heparan sulfate remodeling enzyme, heparan sulfate 6-O-endosulfatase sulfatase FP2, in the rat nervous system. Nagamine S, et al. Brain Res Dev Brain Res, 2005 Oct 6. PMID 16139897
  3. Sulfatase 2 mediates, partially, the expression of endothelin-1 and the additive effect of Ang II-induced endothelin-1 expression by CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats. Kim HY, et al. Cytokine, 2019 Feb. PMID 30470661
  4. Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing. Zaman G, et al. Histochem Cell Biol, 2016 Jan. PMID 26464246
  5. Functional consequences of the subdomain organization of the sulfs. Tang R, et al. J Biol Chem, 2009 Aug 7. PMID 19520866, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that Sulf2 is an up-regulatory factor in the additive action of CXCL8 via the AT1 R pathway on Ang II-induced ET-1 expression in vascular smooth muscle cells under hypertension environment.
    Title: Sulfatase 2 mediates, partially, the expression of endothelin-1 and the additive effect of Ang II-induced endothelin-1 expression by CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats.
  2. Examination of epiphyseal growth plates revealed differential, inverse patterns of SULF1 and SULF2 expressions, with the former enriched in quiescent and the latter in hypertrophic chondrocyte zones.
    Title: Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.
  3. It is proposed that Sulf1, Sulf2 and ErbB1 are involved in the inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system.
    Title: Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro.
  4. the cleavage of rat Sulf2 occurs at two arginine residues, 543 and 570, in the hydrophilic domain.
    Title: Proteolytic cleavage of the rat heparan sulfate 6-O-endosulfatase SulfFP2 by furin-type proprotein convertases.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine-6-sulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables arylsulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in cartilage development ISO
Inferred from Sequence Orthology
more info
  
involved_in chondrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
  
involved_in esophagus smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in glial cell-derived neurotrophic factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in glomerular basement membrane development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glomerular basement membrane development ISO
Inferred from Sequence Orthology
more info
  
involved_in glomerular filtration ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in innervation ISO
Inferred from Sequence Orthology
more info
  
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within liver regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelin production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vascular endothelial growth factor production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
extracellular sulfatase Sulf-2
Names
sulfatase FP2
NP_001030099.1
XP_006235658.1
XP_038961065.1
XP_063139951.1
XP_063139952.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034927.1 → NP_001030099.1  extracellular sulfatase Sulf-2 precursor

    See identical proteins and their annotated locations for NP_001030099.1

    Status: PROVISIONAL

    Source sequence(s)
    AY742216
    UniProtKB/TrEMBL
    A6JXG7, B2GUU3, F7F080, Q3L472
    Related
    ENSRNOP00000008478.4, ENSRNOT00000008478.5
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    175241322..175323808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235596.5 → XP_006235658.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006235658.1

    UniProtKB/TrEMBL
    A6JXG7, B2GUU3, F7F080, Q3L472
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases

  2. XM_063283881.1 → XP_063139951.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/TrEMBL
    A6JXG7, F7F080, Q3L472

  3. XM_039105137.2 → XP_038961065.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/TrEMBL
    A6JXG7, B2GUU3, F7F080, Q3L472
    Related
    ENSRNOP00000085144.1
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases

  4. XM_063283882.1 → XP_063139952.1  extracellular sulfatase Sulf-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GCI2
Nucleotide Protein Strain
Heading Accession and Version

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