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CG4325 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31167, updated on 11-Apr-2024

Summary

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Official Symbol
CG4325provided by FlyBase
Primary source
FLYBASE:FBgn0026878
Locus tag
Dmel_CG4325
See related
AllianceGenome:FB:FBgn0026878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4325; EG:22E5.12
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in positive regulation of antibacterial peptide biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
2C7-2C7; 1-0.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2042730..2043818, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1936763..1937851, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene alpha actinin Neighboring gene mir-4954 stem loop Neighboring gene ultraspiracle Neighboring gene uncharacterized protein Neighboring gene moody Neighboring gene antisense RNA:CR44896 Neighboring gene Salt-inducible kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling. Wahlström G, et al. Mech Dev, 2006 Nov. PMID 17008069
  2. moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Bainton RJ, et al. Cell, 2005 Oct 7. PMID 16213219
  3. Tissue-autonomous EcR functions are required for concurrent organ morphogenesis in the Drosophila embryo. Chavoshi TM, et al. Mech Dev, 2010 May-Jun. PMID 20093179
  4. Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. Valanne S, et al. J Immunol, 2010 Jun 1. PMID 20421637
  5. Modeling spinal muscular atrophy in Drosophila. Chang HC, et al. PLoS One, 2008 Sep 15. PMID 18791638, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of antibacterial peptide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4325-PA
CG4325-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2042730..2043818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272240.1 → NP_001259169.1  uncharacterized protein Dmel_CG4325, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259169.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V6Q6, Q9XZS4
    Conserved Domains (2) summary
    pfam13639
    Location:8 → 49
    zf-RING_2; Ring finger domain
    cl09111
    Location:112 → 151
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  2. NM_130613.3 → NP_569969.1  uncharacterized protein Dmel_CG4325, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569969.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V6Q6, Q9XZS4
    Related
    FBpp0070328
    Conserved Domains (2) summary
    pfam13639
    Location:8 → 49
    zf-RING_2; Ring finger domain
    cl09111
    Location:112 → 151
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XZS4 Q9XZS4

Gene LinkOut

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