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moody [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31168, updated on 4-Apr-2024

Summary

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Official Symbol
moodyprovided by FlyBase
Primary source
FLYBASE:FBgn0025631
Locus tag
Dmel_CG4322
See related
AllianceGenome:FB:FBgn0025631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1631; CG4322; Dmel\CG4322; EG:22E5.11; EP1631; Moody
Summary
Predicted to enable G protein-coupled receptor activity. Involved in several processes, including behavioral response to cocaine; behavioral response to ethanol; and central nervous system development. Located in plasma membrane and pleated septate junction. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; glial cell; imaginal disc; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including MTNR1A (melatonin receptor 1A) and MTNR1B (melatonin receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
2C7-2C8; 1-0.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2044292..2050120, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1938325..1944153, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene alpha actinin Neighboring gene ultraspiracle Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44896 Neighboring gene Salt-inducible kinase 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in Drosophila. Schwabe T, et al. Biol Open, 2017 Feb 15. PMID 28108476, Free PMC Article
  2. Oatp58Dc contributes to blood-brain barrier function by excluding organic anions from the Drosophila brain. Seabrooke S, et al. Am J Physiol Cell Physiol, 2013 Sep. PMID 23804204
  3. Investigation of Evolutionary History and Origin of the Tre1 Family Suggests a Role in Regulating Hemocytes Cells Infiltration of the Blood-Brain Barrier. Kubick N, et al. Insects, 2021 Sep 29. PMID 34680651, Free PMC Article
  4. TU-tagging: cell type-specific RNA isolation from intact complex tissues. Miller MR, et al. Nat Methods, 2009 Jun. PMID 19430475, Free PMC Article
  5. Downregulation of oxidative stress-mediated glial innate immune response suppresses seizures in a fly epilepsy model. Nukala KM, et al. Cell Rep, 2023 Jan 31. PMID 36641750, Free PMC Article

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood-brain barrier formation and maturation.
    Title: The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood-brain barrier formation and maturation.
  2. RNAi-based screens uncover a potential new role for the orphan neuropeptide receptor Moody in Drosophila female germline stem cell maintenance.
    Title: RNAi-based screens uncover a potential new role for the orphan neuropeptide receptor Moody in Drosophila female germline stem cell maintenance.
  3. The results suggest a mechanism by which the Drosophila BBB is maintained by Moody/GPCR-dependent formation of ARSs, which is supported by myosin activation.
    Title: The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in axon ensheathment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to nicotine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of glial blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral cord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pleated septate junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
moody
Names
CG4322-PA
CG4322-PB
CG4322-PC
CG4322-PD
CG4322-PE
CG4322-PF
moody receptor
moody-PA
moody-PB
moody-PC
moody-PD
moody-PE
moody-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2044292..2050120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201607.2 → NP_001188536.1  moody, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188536.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MS14
    Conserved Domains (2) summary
    pfam00001
    Location:53 → 363
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44 → 167
    7tm_4; Olfactory receptor

  2. NM_001201605.2 → NP_001188534.1  moody, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188534.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77270, Q8MRD0, Q9W534
    UniProtKB/TrEMBL
    M9PDK4
    Conserved Domains (2) summary
    pfam00001
    Location:53 → 363
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44 → 167
    7tm_4; Olfactory receptor

  3. NM_001272241.2 → NP_001259170.1  moody, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259170.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77270, Q8MRD0, Q9W534
    UniProtKB/TrEMBL
    M9PDK4
    Conserved Domains (2) summary
    pfam00001
    Location:53 → 363
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44 → 167
    7tm_4; Olfactory receptor

  4. NM_001201606.2 → NP_001188535.1  moody, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188535.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MS14
    Conserved Domains (2) summary
    pfam00001
    Location:53 → 363
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44 → 167
    7tm_4; Olfactory receptor

  5. NM_130614.4 → NP_569970.2  moody, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569970.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77270, Q8MRD0, Q9W534
    UniProtKB/TrEMBL
    M9PDK4
    Related
    FBpp0070327
    Conserved Domains (2) summary
    pfam00001
    Location:53 → 363
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44 → 167
    7tm_4; Olfactory receptor

  6. NM_001272242.2 → NP_001259171.1  moody, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259171.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77270, Q8MRD0, Q9W534
    UniProtKB/TrEMBL
    M9PDK4
    Conserved Domains (2) summary
    pfam00001
    Location:53 → 363
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44 → 167
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MS14 M9MS14
M9PDK4 M9PDK4
Q9W534.2 Q9W534

Gene LinkOut

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