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Kmt2e lysine methyltransferase 2E [ Rattus norvegicus (Norway rat) ]

Gene ID: 311968, updated on 11-Apr-2024

Summary

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Official Symbol
Kmt2eprovided by RGD
Official Full Name
lysine methyltransferase 2Eprovided by RGD
Primary source
RGD:1309641
See related
Ensembl:ENSRNOG00000021614 AllianceGenome:RGD:1309641
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mll5
Summary
Predicted to enable enzyme binding activity and methylated histone binding activity. Predicted to be involved in several processes, including neutrophil activation; positive regulation of G1/S transition of mitotic cell cycle; and positive regulation of nitrogen compound metabolic process. Predicted to be located in nuclear body and transcriptionally active chromatin. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Orthologous to human KMT2E (lysine methyltransferase 2E (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 174.2), Thymus (RPKM 173.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q11
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (12550570..12655329, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (11658218..11727373, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (8187751..8255578, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD93 Neighboring gene uncharacterized LOC134486545 Neighboring gene SRSF protein kinase 2 Neighboring gene uncharacterized LOC120102473 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Targeted silencing of MLL5β inhibits tumor growth and promotes gamma-irradiation sensitization in HPV16/18-associated cervical cancers. Nin DS, et al. Mol Cancer Ther, 2014 Nov. PMID 25172963
  2. The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity. Mas-Y-Mas S, et al. PLoS One, 2016. PMID 27812132, Free PMC Article
  3. Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study. Lucena-Araujo AR, et al. Br J Haematol, 2014 Aug. PMID 24796963
  4. Solution NMR structure and histone binding of the PHD domain of human MLL5. Lemak A, et al. PLoS One, 2013. PMID 24130829, Free PMC Article
  5. Molecular basis for chromatin binding and regulation of MLL5. Ali M, et al. Proc Natl Acad Sci U S A, 2013 Jul 9. PMID 23798402, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables histone H3 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil activation ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Rpd3L-Expanded complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inactive histone-lysine N-methyltransferase 2E
Names
histone-lysine N-methyltransferase 2E
histone-lysine N-methyltransferase MLL5
lysine (K)-specific methyltransferase 2E
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
NP_001094321.2
XP_063142017.1
XP_063142018.1
XP_063142019.1
XP_063142020.1
XP_063142021.1
XP_063142022.1
XP_063142023.1
XP_063142024.1
XP_063142025.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100851.2 → NP_001094321.2  inactive histone-lysine N-methyltransferase 2E

    Status: PROVISIONAL

    Source sequence(s)
    CK367010, JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JWF0, A0A8I6ASP1
    Related
    ENSRNOP00000097446.1, ENSRNOT00000075902.3
    Conserved Domains (5) summary
    PHA03247
    Location:1307 → 1612
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:483 → 716
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK03427
    Location:1737 → 1845
    PRK03427; cell division protein ZipA; Provisional
    cd15550
    Location:120 → 163
    PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
    cd19182
    Location:324 → 451
    SET_KMT2E; SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    12550570..12655329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285953.1 → XP_063142023.1  inactive histone-lysine N-methyltransferase 2E isoform X3

  2. XM_063285952.1 → XP_063142022.1  inactive histone-lysine N-methyltransferase 2E isoform X2

  3. XM_063285947.1 → XP_063142017.1  inactive histone-lysine N-methyltransferase 2E isoform X1

    UniProtKB/TrEMBL
    A0A8I6ASP1

  4. XM_063285949.1 → XP_063142019.1  inactive histone-lysine N-methyltransferase 2E isoform X1

    UniProtKB/TrEMBL
    A0A8I6ASP1

  5. XM_063285951.1 → XP_063142021.1  inactive histone-lysine N-methyltransferase 2E isoform X1

    UniProtKB/TrEMBL
    A0A8I6ASP1

  6. XM_063285948.1 → XP_063142018.1  inactive histone-lysine N-methyltransferase 2E isoform X1

    UniProtKB/TrEMBL
    A0A8I6ASP1

  7. XM_063285950.1 → XP_063142020.1  inactive histone-lysine N-methyltransferase 2E isoform X1

    UniProtKB/TrEMBL
    A0A8I6ASP1

  8. XM_063285954.1 → XP_063142024.1  inactive histone-lysine N-methyltransferase 2E isoform X4

  9. XM_063285955.1 → XP_063142025.1  inactive histone-lysine N-methyltransferase 2E isoform X5

RNA

  1. XR_010065633.1 RNA Sequence

  2. XR_010065634.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
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Research Materials
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