Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ezh2provided by RGD
Official Full Name: enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by RGD
Primary source: RGD:1595860
See related: Ensembl:ENSRNOG00000006048 AllianceGenome:RGD:1595860
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including histone H3-K27 methylation; negative regulation of macromolecule metabolic process; and positive regulation of dendrite development. Located in cytoplasm and nucleus. Used to study endometriosis. Biomarker of leiomyoma; non-alcoholic fatty liver disease; and pancreatic cancer. Human ortholog(s) of this gene implicated in Weaver syndrome; bone cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 228.6), Spleen (RPKM 107.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (77624223..77698598, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (76624399..76687362, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (77284404..77347011, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcineurin/NFATc3 pathway mediates myocardial fibrosis in diabetes by impairing enhancer of zeste homolog 2 of cardiac fibroblasts.
Title: Calcineurin/NFATc3 pathway mediates myocardial fibrosis in diabetes by impairing enhancer of zeste homolog 2 of cardiac fibroblasts.
Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10 axis in rats with depressive-like behaviors.
Title: Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10 axis in rats with depressive-like behaviors.
Histone methyltransferase enzyme enhancer of zeste homolog 2 counteracts ischemic brain injury via H3K27me3-mediated regulation of PI3K/AKT/mTOR signaling pathway.
Title: Histone methyltransferase enzyme enhancer of zeste homolog 2 counteracts ischemic brain injury via H3K27me3-mediated regulation of PI3K/AKT/mTOR signaling pathway.
Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal mesothelial cells mediated by klotho.
Title: Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal mesothelial cells mediated by klotho.
EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway.
Title: EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway.
EZH2-mediated suppression of CLDN1 leads to barrier dysfunction in PPI-refractory gastroesophageal reflux disease.
Title: EZH2-mediated suppression of CLDN1 leads to barrier dysfunction in PPI-refractory gastroesophageal reflux disease.
EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR-129-5p.
Title: EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR-129-5p.
Histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit exacerbates inflammation in depression rats by modulating microglia polarization.
Title: Histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit exacerbates inflammation in depression rats by modulating microglia polarization.
EZH2 Mediates miR-146a-5p/HIF-1alpha to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury.
Title: EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury.
Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain.
Title: Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain.

Submit: New GeneRIF Correction See all GeneRIFs (37)

General gene information

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Markers

D4Mit6 (e-PCR), detects polymorphism
- UniSTS:463386

U52951 (e-PCR)
- UniSTS:125771

AU026702 (e-PCR)
- UniSTS:114021

RH125972 (e-PCR)
- UniSTS:162684

PMC87093P1 (e-PCR)
- UniSTS:273577

Ezh2 (e-PCR), detects polymorphism
- UniSTS:143053

UniSTS:143054 (e-PCR)
- UniSTS:143054

Ezh2 (e-PCR), detects polymorphism
- UniSTS:143054

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H3K27 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K27 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables primary miRNA binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA methylation-dependent heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G1 to G0 transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to trichostatin A	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in facultative heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hepatocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver regeneration	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of striated muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gliogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of kidney development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulatory ncRNA-mediated heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to tetrachloromethane	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in subtelomeric heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
part_of chromatin silencing complex	ISO Inferred from Sequence Orthology more info
is_active_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of pericentric heterochromatin	ISO Inferred from Sequence Orthology more info
located_in pronucleus	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase EZH2

Names: enhancer of zeste homolog 2

NP_001128451.1

EC 2.1.1.354

XP_006236463.1

EC 2.1.1.354

XP_006236464.1

EC 2.1.1.354

XP_006236465.1

EC 2.1.1.354

XP_006236466.1

EC 2.1.1.354

XP_006236467.1

EC 2.1.1.354

XP_006236468.1

EC 2.1.1.354

XP_006236470.1

EC 2.1.1.354

XP_038963458.1

EC 2.1.1.354

XP_038963460.1

EC 2.1.1.354

XP_038963461.1

EC 2.1.1.354

XP_038963462.1

EC 2.1.1.354

XP_038963463.1

EC 2.1.1.354

XP_063142080.1

EC 2.1.1.354

XP_063142081.1

EC 2.1.1.354

XP_063142082.1

EC 2.1.1.354

XP_063142083.1

EC 2.1.1.354

XP_063142084.1

EC 2.1.1.354

XP_063142085.1

EC 2.1.1.354

XP_063142086.1

EC 2.1.1.354

XP_063142087.1

EC 2.1.1.354

XP_063142088.1

EC 2.1.1.354

XP_063142089.1

EC 2.1.1.354

XP_063142090.1

EC 2.1.1.354

XP_063142091.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134979.1 → NP_001128451.1 histone-lysine N-methyltransferase EZH2

See identical proteins and their annotated locations for NP_001128451.1

Status: PROVISIONAL

Source sequence(s)

CH473959

UniProtKB/TrEMBL

A0A8I5ZPT6, B5DFE2, F7F5Z0

Related

ENSRNOP00000008149.4, ENSRNOT00000008149.6

Conserved Domains (4) summary

cd19218
Location:609 → 728

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:559 → 590

preSET_CXC; CXC domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

77624223..77698598 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286021.1 → XP_063142091.1 histone-lysine N-methyltransferase EZH2 isoform X8
XM_063286013.1 → XP_063142083.1 histone-lysine N-methyltransferase EZH2 isoform X4
XM_063286019.1 → XP_063142089.1 histone-lysine N-methyltransferase EZH2 isoform X7
XM_006236405.5 → XP_006236467.1 histone-lysine N-methyltransferase EZH2 isoform X3

See identical proteins and their annotated locations for XP_006236467.1

UniProtKB/TrEMBL

A0A8I6GAA5

Conserved Domains (4) summary

cd19218
Location:605 → 724

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:149 → 240

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:555 → 586

preSET_CXC; CXC domain
XM_063286018.1 → XP_063142088.1 histone-lysine N-methyltransferase EZH2 isoform X6

UniProtKB/TrEMBL

A0A8I6GJI6
XM_063286015.1 → XP_063142085.1 histone-lysine N-methyltransferase EZH2 isoform X5
XM_006236402.5 → XP_006236464.1 histone-lysine N-methyltransferase EZH2 isoform X1

See identical proteins and their annotated locations for XP_006236464.1

UniProtKB/TrEMBL

A0A8I5ZPT6

Conserved Domains (4) summary

cd19218
Location:614 → 733

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:564 → 595

preSET_CXC; CXC domain
XM_006236408.5 → XP_006236470.1 histone-lysine N-methyltransferase EZH2 isoform X8

UniProtKB/TrEMBL

A0A8I6GAA5

Conserved Domains (4) summary

cd19218
Location:558 → 677

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:149 → 240

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:508 → 539

preSET_CXC; CXC domain
XM_006236406.5 → XP_006236468.1 histone-lysine N-methyltransferase EZH2 isoform X4

UniProtKB/TrEMBL

A0A8I6GAA5

Conserved Domains (4) summary

cd19218
Location:600 → 719

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:149 → 240

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:550 → 581

preSET_CXC; CXC domain
XM_006236404.5 → XP_006236466.1 histone-lysine N-methyltransferase EZH2 isoform X3

See identical proteins and their annotated locations for XP_006236466.1

UniProtKB/TrEMBL

A0A8I6GAA5

Conserved Domains (4) summary

cd19218
Location:605 → 724

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:149 → 240

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:555 → 586

preSET_CXC; CXC domain
XM_063286016.1 → XP_063142086.1 histone-lysine N-methyltransferase EZH2 isoform X6

UniProtKB/TrEMBL

A0A8I6GJI6
XM_006236403.5 → XP_006236465.1 histone-lysine N-methyltransferase EZH2 isoform X2

See identical proteins and their annotated locations for XP_006236465.1

UniProtKB/TrEMBL

A0A8I5ZPT6, B5DFE2, F7F5Z0

Related

ENSRNOP00000092431.1

Conserved Domains (4) summary

cd19218
Location:609 → 728

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:559 → 590

preSET_CXC; CXC domain
XM_006236401.5 → XP_006236463.1 histone-lysine N-methyltransferase EZH2 isoform X1

See identical proteins and their annotated locations for XP_006236463.1

UniProtKB/TrEMBL

A0A8I5ZPT6

Conserved Domains (4) summary

cd19218
Location:614 → 733

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:564 → 595

preSET_CXC; CXC domain
XM_063286017.1 → XP_063142087.1 histone-lysine N-methyltransferase EZH2 isoform X6

UniProtKB/TrEMBL

A0A8I6GJI6
XM_063286020.1 → XP_063142090.1 histone-lysine N-methyltransferase EZH2 isoform X8
XM_063286010.1 → XP_063142080.1 histone-lysine N-methyltransferase EZH2 isoform X1
XM_063286014.1 → XP_063142084.1 histone-lysine N-methyltransferase EZH2 isoform X4
XM_063286011.1 → XP_063142081.1 histone-lysine N-methyltransferase EZH2 isoform X2

UniProtKB/TrEMBL

B5DFE2, F7F5Z0
XM_063286012.1 → XP_063142082.1 histone-lysine N-methyltransferase EZH2 isoform X3
XM_039107530.2 → XP_038963458.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZPT6

Conserved Domains (4) summary

cd19218
Location:614 → 733

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:564 → 595

preSET_CXC; CXC domain
XM_039107532.1 → XP_038963460.1 histone-lysine N-methyltransferase EZH2 isoform X9

UniProtKB/TrEMBL

A0A8I6AHI4

Conserved Domains (3) summary

cd19218
Location:505 → 624

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam18118
Location:49 → 140

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:455 → 486

preSET_CXC; CXC domain
XM_039107533.2 → XP_038963461.1 histone-lysine N-methyltransferase EZH2 isoform X9

UniProtKB/TrEMBL

A0A8I6AHI4

Conserved Domains (3) summary

cd19218
Location:505 → 624

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam18118
Location:49 → 140

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:455 → 486

preSET_CXC; CXC domain
XM_039107535.2 → XP_038963463.1 histone-lysine N-methyltransferase EZH2 isoform X11

Conserved Domains (2) summary

cd19218
Location:372 → 491

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam18264
Location:322 → 353

preSET_CXC; CXC domain
XM_039107534.2 → XP_038963462.1 histone-lysine N-methyltransferase EZH2 isoform X10

Conserved Domains (2) summary

cd19218
Location:377 → 496

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam18264
Location:327 → 358

preSET_CXC; CXC domain