Doxl1 diamine oxidase-like protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Doxl1provided by RGD
Official Full Name: diamine oxidase-like protein 1provided by RGD
Primary source: RGD:735023
See related: Ensembl:ENSRNOG00000023612 AllianceGenome:RGD:735023
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable copper ion binding activity; diamine oxidase activity; and primary amine oxidase activity. Predicted to be involved in amine metabolic process and response to antibiotic. Predicted to be active in plasma membrane. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 4q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (79210298..79213914)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (77879428..77883044)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (78563625..78567241)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables diamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables primary amine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables quinone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to antibiotic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: diamine oxidase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199233.1 → NP_954703.1 diamine oxidase-like protein 1 precursor

See identical proteins and their annotated locations for NP_954703.1

Status: PROVISIONAL

Source sequence(s)

BK001313

UniProtKB/TrEMBL

F7FN84, Q6IMK6

Related

ENSRNOP00000033821.3, ENSRNOT00000032300.3

Conserved Domains (3) summary

pfam01179
Location:308 → 696

Cu_amine_oxid; Copper amine oxidase, enzyme domain

pfam02727
Location:45 → 130

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam02728
Location:146 → 246

Cu_amine_oxidN3; Copper amine oxidase, N3 domain