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Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312320, updated on 30-Sep-2021

Summary

Official Symbol
Igf2bp3provided by RGD
Official Full Name
insulin-like growth factor 2 mRNA binding protein 3provided by RGD
Primary source
RGD:1306512
See related
EnsemblRapid:ENSRNOG00000009052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab2-255; RGD1306512
Expression
Biased expression in Liver (RPKM 123.2), Testes (RPKM 66.8) and 6 other tissues See more
Orthologs
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Genomic context

See Igf2bp3 in Genome Data Viewer
Location:
4q24
Exon count:
19
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (78060494..78195007, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78744683..78879457, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene glycoprotein nmb Neighboring gene mitochondrial assembly of ribosomal large subunit 1 Neighboring gene transformer 2 alpha homolog Neighboring gene gem (nuclear organelle) associated protein 7-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of RNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor 2 mRNA-binding protein 3
Names
insulin-like growth factor 2, binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372112.1NP_001359041.1  insulin-like growth factor 2 mRNA-binding protein 3

    Status: VALIDATED

    Source sequence(s)
    AA998402, JACYVU010000142
    Related
    ENSRNOP00000071626.1, ENSRNOT00000084543.2
    Conserved Domains (4) summary
    cd00105
    Location:279344
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:407470
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cd12630
    Location:81156
    RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cl17169
    Location:177
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    78060494..78195007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107552.1XP_038963480.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

    Conserved Domains (6) summary
    cd12630
    Location:81156
    RRM2_IGF2BP3; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cd22492
    Location:197272
    KH-I_IGF2BP3_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and similar proteins
    cd22498
    Location:451528
    KH-I_IGF2BP3_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and similar proteins
    cd22499
    Location:536611
    KH-I_IGF2BP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
    cl00098
    Location:275359
    KH-I; K homology (KH) RNA-binding domain, type I
    cl17169
    Location:177
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_017592993.2XP_017448482.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X3

  3. XM_039107554.1XP_038963482.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X2

    Conserved Domains (5) summary
    cd12630
    Location:2196
    RRM2_IGF2BP3; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cd22492
    Location:137212
    KH-I_IGF2BP3_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and similar proteins
    cd22498
    Location:391468
    KH-I_IGF2BP3_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and similar proteins
    cl00098
    Location:215299
    KH-I; K homology (KH) RNA-binding domain, type I
    cl17169
    Location:117
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_039107555.1XP_038963483.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X2

    Conserved Domains (5) summary
    cd12630
    Location:2196
    RRM2_IGF2BP3; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cd22492
    Location:137212
    KH-I_IGF2BP3_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and similar proteins
    cd22498
    Location:391468
    KH-I_IGF2BP3_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and similar proteins
    cl00098
    Location:215299
    KH-I; K homology (KH) RNA-binding domain, type I
    cl17169
    Location:117
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_039107556.1XP_038963484.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X4

    Conserved Domains (2) summary
    cd22498
    Location:188265
    KH-I_IGF2BP3_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and similar proteins
    cl00098
    Location:1296
    KH-I; K homology (KH) RNA-binding domain, type I

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047888.1: Suppressed sequence

    Description
    NM_001047888.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: IGF2BP3 (GeneID:420617).
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