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HLA-DRB2 major histocompatibility complex, class II, DR beta 2 (pseudogene) [ Homo sapiens (human) ]

Gene ID: 3124, updated on 11-Nov-2023

Summary

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Official Symbol
HLA-DRB2provided by HGNC
Official Full Name
major histocompatibility complex, class II, DR beta 2 (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:4950
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLA-DR2B
Annotation information
Annotation category: only annotated on alternate loci in reference assembly
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Genomic context

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Location:
6p21.3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 (ALT_REF_LOCI_2) NT_113891.3 (3972319..3987751, complement)
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 (ALT_REF_LOCI_6) NT_167248.2 (3753332..3768710, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (32383211..32398640, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 Unlocalized Scaffold (ALT_REF_LOCI_2) NT_113891.2 (3972425..3987857, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 Unlocalized Scaffold (ALT_REF_LOCI_6) NT_167248.1 (3758928..3774306, complement)

NT_113891.3Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 79, pseudogene Neighboring gene major histocompatibility complex, class II, DR beta 3 Neighboring gene RNA, U1 small nuclear 116, pseudogene Neighboring gene major histocompatibility complex, class II, DR beta 1

NT_167248.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905397 Neighboring gene major histocompatibility complex, class II, DR beta 3 Neighboring gene RNA, U1 small nuclear 116, pseudogene Neighboring gene major histocompatibility complex, class II, DR beta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of an HLA-DR beta pseudogene in the DRw52 supertypic group. Rollini P, et al. Immunogenetics, 1987. PMID 3032786
  2. [Association study between HLA-DRB genes and asthmatic children]. Zhao J, et al. Zhonghua Yi Xue Za Zhi, 2009 Aug 25. PMID 20095337
  3. A novel HLA-DRB1-DR2 allele associated with HLA mistyping. Rosenlicht JW, et al. Immunogenetics, 1993. PMID 8436426
  4. [Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen (author's transl)]. Kratzin H, et al. Hoppe Seylers Z Physiol Chem, 1981 Dec. PMID 6947956
  5. The evolutionary origin of the HLA-DR3 haplotype. Vincek V, et al. Immunogenetics, 1992. PMID 1541486

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The allele HLA-DR2 (15) is correlated with the susceptibility to childhood asthma, whereas it is not related with the severity of asthma.
    Title: [Association study between HLA-DRB genes and asthmatic children].
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis.
Submit: New GeneRIF Correction

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Clone Names

  • MGC120245

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_056116.1 

    Range
    101..15533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    3972319..3987751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    3753332..3768710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    32383211..32398640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037638.1: Suppressed sequence

    Description
    NM_001037638.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version

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