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Rbsn rabenosyn, RAB effector [ Rattus norvegicus (Norway rat) ]

Gene ID: 312562, updated on 5-Mar-2024

Summary

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Symbol
Rbsnprovided by RGD
Full Name
rabenosyn, RAB effectorprovided by RGD
Primary source
RGD:1305397
See related
Ensembl:ENSRNOG00000011391 AllianceGenome:RGD:1305397
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfyve20
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to lysosome transport; early endosome to Golgi transport; and regulation of Golgi organization. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 83.0), Brain (RPKM 82.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (126239354..126269702, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (124682228..124712578, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (124050559..124080919, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2, group C, member 2 Neighboring gene uncharacterized LOC103692187 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene uncharacterized LOC134486818 Neighboring gene thyrotropin releasing hormone Neighboring gene prickle planar cell polarity protein 2 Neighboring gene uncharacterized LOC134486613

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology. Naslavsky N, et al. J Cell Sci, 2009 Feb 1. PMID 19139087, Free PMC Article
  2. Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Mishra A, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534488, Free PMC Article
  3. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in early endosome to Golgi transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rabenosyn-5
Names
zinc finger, FYVE domain containing 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107875.1 → NP_001101345.1  rabenosyn-5

    See identical proteins and their annotated locations for NP_001101345.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473957
    UniProtKB/TrEMBL
    A6IBC3, D3ZL11
    Related
    ENSRNOP00000015602.3, ENSRNOT00000015602.5
    Conserved Domains (3) summary
    cd15716
    Location:150 → 261
    FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
    pfam11464
    Location:460 → 498
    Rbsn; Rabenosyn Rab binding domain
    pfam16601
    Location:548 → 726
    NPF; Rabosyn-5 repeating NPF sequence-motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    126239354..126269702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107619.2 → XP_038963547.1  rabenosyn-5 isoform X4

    Conserved Domains (3) summary
    cd15716
    Location:62 → 173
    FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
    pfam11464
    Location:372 → 410
    Rbsn; Rabenosyn Rab binding domain
    pfam16601
    Location:460 → 638
    NPF; Rabosyn-5 repeating NPF sequence-motif

  2. XM_039107618.2 → XP_038963546.1  rabenosyn-5 isoform X1

    Conserved Domains (3) summary
    cd15716
    Location:148 → 259
    FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
    pfam11464
    Location:458 → 496
    Rbsn; Rabenosyn Rab binding domain
    pfam16601
    Location:546 → 724
    NPF; Rabosyn-5 repeating NPF sequence-motif

  3. XM_063286076.1 → XP_063142146.1  rabenosyn-5 isoform X3

  4. XM_006236908.5 → XP_006236970.1  rabenosyn-5 isoform X2

    Conserved Domains (3) summary
    cd15716
    Location:120 → 231
    FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
    pfam11464
    Location:427 → 466
    Rbsn; Rabenosyn Rab binding domain
    pfam16601
    Location:518 → 696
    NPF; Rabosyn-5 repeating NPF sequence-motif
Nucleotide Protein Strain
Heading Accession and Version

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