w white [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wprovided by FlyBase
Official Full Name: whiteprovided by FlyBase
Primary source: FLYBASE:FBgn0003996
Locus tag: Dmel_CG2759
See related: AllianceGenome:FB:FBgn0003996
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BACN33B1.1; c23; CG2759; Dmel\CG2759; DmWhite; DMWHITE; e(g); EG:BACN33B1.1; m(g); mini-white; mw; W; w(AT)[[13]]; White
Summary: Enables amine transmembrane transporter activity; organic anion transmembrane transporter activity; and purine nucleobase transmembrane transporter activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; organic anion transport; and purine nucleobase transport. Located in cytoplasmic vesicle membrane and pigment granule. Is integral component of pigment granule membrane. Is expressed in Malpighian tubule; embryonic/larval fat body; head; and visual system. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1); ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)); and ABCG4 (ATP binding cassette subfamily G member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 3B6-3B6; 1-1.5 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2790599..2796466, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2684632..2690499, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Frequency-specific modification of locomotor components by the white gene in Drosophila melanogaster adult flies.
Title: Frequency-specific modification of locomotor components by the white gene in Drosophila melanogaster adult flies.
Mutants of the white ABCG Transporter in Drosophila melanogaster Have Deficient Olfactory Learning and Cholesterol Homeostasis.
Title: Mutants of the white ABCG Transporter in Drosophila melanogaster Have Deficient Olfactory Learning and Cholesterol Homeostasis.
white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila.
Title: white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila.
CRISPR/Cas9 mediated disruption of the white gene leads to pigmentation deficiency and copulation failure in Drosophila suzukii.
Title: CRISPR/Cas9 mediated disruption of the white gene leads to pigmentation deficiency and copulation failure in Drosophila suzukii.
The findings of this study highlight the rhythmic light stimulation-evoked modifications of walking behavior in w(1118) flies.
Title: Walking behavior in a circular arena modified by pulsed light stimulation in Drosophila melanogaster w(1118) line.
Using a transgenic lines, we show that the Fab-7 insulator of the bithorax complex and the MDG4 (gypsy) insulator are able to disrupt weak transcription derived from the enhancer regulating the white gene expression in the eyes.
Title: [Insulators can disrupt weak transcription derived from the white gene enhancer in Drosophila transgenic lines].
data suggest that a White-cGMP interaction modulates the timing of locomotor recovery from anoxia
Title: White - cGMP Interaction Promotes Fast Locomotor Recovery from Anoxia in Adult Drosophila.
Data suggest that age-dependent behavioral/physiological changes differ between wide-type flies (Canton-S flies) and genetically engineered flies null mutation of white gene (w1118 flies); old w1118 flies exhibit decreased path length per minute and reduced 0.2 s path increment compared with young flies, whereas old Canton-S flies exhibit same path length per minute and same 0.2 s path increment compared with young flies.
Title: Different age-dependent performance in Drosophila wild-type Canton-S and the white mutant w1118 flies.
White modulates the timing of locomotor recovery from anoxia.
Title: Timing of Locomotor Recovery from Anoxia Modulated by the white Gene in Drosophila.
the negative effect of transcription of the Drosophila genes white and yellow remained, but weakened with increased distance between the leading promoter and enhancer and with decreased distance between the enhancer and target promoter
Title: [The Effect of Transcription on Enhancer Activity in Drosophila melanogaster].

Submit: New GeneRIF Correction See all GeneRIFs (22)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ABC-type 3',5'-cyclic GMP transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ABC-type guanine transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-tryptophan transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables amine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables riboflavin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xanthine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biogenic amine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGMP transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye pigment metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in eye pigment precursor transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in eye pigment precursor transport	TAS Traceable Author Statement more info	PubMed
involved_in gravitaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in guanine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histamine uptake	IGI Inferred from Genetic Interaction more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in riboflavin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tryptophan transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xanthine transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in pigment granule	IDA Inferred from Direct Assay more info	PubMed
located_in pigment granule membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info