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Tmem68 transmembrane protein 68 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312946, updated on 11-Apr-2024

Summary

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Official Symbol
Tmem68provided by RGD
Official Full Name
transmembrane protein 68provided by RGD
Primary source
RGD:1309006
See related
Ensembl:ENSRNOG00000008872 AllianceGenome:RGD:1309006
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309006
Summary
Predicted to enable acyltransferase activity. Predicted to be integral component of membrane. Orthologous to human TMEM68 (transmembrane protein 68). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 75.6), Kidney (RPKM 63.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem68 in Genome Data Viewer
Location:
5q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (21291675..21322443, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (16494054..16524842, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (16363908..16413307, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene XK related 4 Neighboring gene uncharacterized LOC103695237 Neighboring gene uncharacterized LOC120103059 Neighboring gene trimethylguanosine synthase 1 Neighboring gene sterol carrier protein 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phospholipid:diacylglycerol acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DGAT1/2-independent enzyme synthesizing storage lipids
NP_001101373.1
XP_006237889.1
XP_006237894.1
XP_038965684.1
XP_038965685.1
XP_038965686.1
XP_038965687.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107903.1 → NP_001101373.1  DGAT1/2-independent enzyme synthesizing storage lipids

    See identical proteins and their annotated locations for NP_001101373.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473984
    UniProtKB/TrEMBL
    A6JFK5, D3ZF19
    Conserved Domains (1) summary
    cd07987
    Location:103 → 309
    LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    21291675..21322443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237827.5 → XP_006237889.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

    See identical proteins and their annotated locations for XP_006237889.1

    UniProtKB/TrEMBL
    A6JFK5, D3ZF19
    Conserved Domains (1) summary
    cd07987
    Location:103 → 309
    LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

  2. XM_006237832.5 → XP_006237894.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X2

    Conserved Domains (1) summary
    cd07987
    Location:103 → 295
    LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

  3. XM_039109759.2 → XP_038965687.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

    UniProtKB/TrEMBL
    A6JFK5, D3ZF19
    Conserved Domains (1) summary
    cd07987
    Location:103 → 309
    LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

  4. XM_039109757.2 → XP_038965685.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

    UniProtKB/TrEMBL
    A6JFK5, D3ZF19
    Related
    ENSRNOP00000012215.3
    Conserved Domains (1) summary
    cd07987
    Location:103 → 309
    LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

  5. XM_039109756.2 → XP_038965684.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

    UniProtKB/TrEMBL
    A6JFK5, D3ZF19
    Conserved Domains (1) summary
    cd07987
    Location:103 → 309
    LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

  6. XM_039109758.2 → XP_038965686.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

    UniProtKB/TrEMBL
    A6JFK5, D3ZF19
    Conserved Domains (1) summary
    cd07987
    Location:103 → 309
    LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

RNA

  1. XR_005504424.2 RNA Sequence

  2. XR_010066376.1 RNA Sequence

  3. XR_005504426.2 RNA Sequence

  4. XR_005504425.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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