Zfp189 zinc finger protein 189 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp189provided by RGD
Official Full Name: zinc finger protein 189provided by RGD
Primary source: RGD:1306510
See related: Ensembl:ENSRNOG00000006972 AllianceGenome:RGD:1306510
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF189 (zinc finger protein 189). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 81.8), Adrenal (RPKM 61.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (68668225..68679606)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (63872596..63884348)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (64789432..64801079)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 189

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107930.1 → NP_001101400.1 zinc finger protein 189

See identical proteins and their annotated locations for NP_001101400.1

Status: PROVISIONAL

Source sequence(s)

CH474056

UniProtKB/TrEMBL

A6KJE3

Conserved Domains (4) summary

cd07765
Location:10 → 39

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

COG5048
Location:116 → 506

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:328 → 348

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:368 → 393

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

68668225..68679606

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238157.4 → XP_006238219.1 zinc finger protein 189 isoform X1

UniProtKB/TrEMBL

D3ZRX1

Related

ENSRNOP00000009584.6

Conserved Domains (4) summary

cd07765
Location:6 → 33

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

COG5048
Location:110 → 500

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:322 → 342

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:362 → 387

zf-H2C2_2; Zinc-finger double domain
XM_039109854.2 → XP_038965782.1 zinc finger protein 189 isoform X3

Conserved Domains (3) summary

COG5048
Location:38 → 428

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:250 → 270

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:459 → 483

zf-H2C2_2; Zinc-finger double domain
XM_039109853.2 → XP_038965781.1 zinc finger protein 189 isoform X2

UniProtKB/TrEMBL

A0A0G2K0C7

Related

ENSRNOP00000071391.2

Conserved Domains (3) summary

COG5048
Location:108 → 498

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:320 → 340

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:529 → 553

zf-H2C2_2; Zinc-finger double domain