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Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313722, updated on 11-Apr-2024

Summary

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Official Symbol
Spsb1provided by RGD
Official Full Name
splA/ryanodine receptor domain and SOCS box containing 1provided by RGD
Primary source
RGD:1309319
See related
Ensembl:ENSRNOG00000017212 AllianceGenome:RGD:1309319
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309319
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytosol. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 60.5), Thymus (RPKM 31.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (165641255..165701482, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (160358292..160418541, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (166913734..166978534, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2, pseudogene 44 Neighboring gene uncharacterized LOC120103040 Neighboring gene uncharacterized LOC102548366 Neighboring gene uncharacterized LOC120103041 Neighboring gene uncharacterized LOC134487038 Neighboring gene hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. Nishiya T, et al. J Biol Chem, 2011 Mar 18. PMID 21199876, Free PMC Article
  2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SPRY domain-containing SOCS box protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107994.2 → NP_001101464.1  SPRY domain-containing SOCS box protein 1

    See identical proteins and their annotated locations for NP_001101464.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158603
    UniProtKB/TrEMBL
    A0A0G2K863, A6IUC3, B0BMX8
    Conserved Domains (2) summary
    cd12906
    Location:54 → 227
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
    cl02533
    Location:232 → 273
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    165641255..165701482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239462.5 → XP_006239524.1  SPRY domain-containing SOCS box protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006239524.1

    UniProtKB/TrEMBL
    A0A0G2K863, A6IUC3, B0BMX8
    Related
    ENSRNOP00000074486.1
    Conserved Domains (2) summary
    cd12906
    Location:54 → 227
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
    cl02533
    Location:232 → 273
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  2. XM_008764258.4 → XP_008762480.1  SPRY domain-containing SOCS box protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008762480.1

    UniProtKB/TrEMBL
    A0A0G2K863, A6IUC3, B0BMX8
    Conserved Domains (2) summary
    cd12906
    Location:54 → 227
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
    cl02533
    Location:232 → 273
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
Nucleotide Protein Strain
Heading Accession and Version

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