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Plch2 phospholipase C, eta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313756, updated on 13-Apr-2024

Summary

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Official Symbol
Plch2provided by RGD
Official Full Name
phospholipase C, eta 2provided by RGD
Primary source
RGD:1304675
See related
Ensembl:ENSRNOG00000014226 AllianceGenome:RGD:1304675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304675
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol-mediated signaling. Predicted to act upstream of or within phosphatidylinositol metabolic process. Predicted to be located in plasma membrane. Orthologous to human PLCH2 (phospholipase C eta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 61.7), Lung (RPKM 8.1) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (170826543..170885012, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (165544209..165613769, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172386400..172455965, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 14 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene pantothenate kinase 4 Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene MORN repeat containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme. Nakahara M, et al. J Biol Chem, 2005 Aug 12. PMID 15899900
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
NP_001413979.1
NP_001413980.1
XP_008762618.2
XP_017449377.1
XP_017449380.1
XP_038967300.1
XP_038967301.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427050.1 → NP_001413979.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  2. NM_001427051.1 → NP_001413980.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    170826543..170885012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764396.4 → XP_008762618.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLE1
    Related
    ENSRNOP00000095956.1

  2. XM_017593891.3 → XP_017449380.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

    UniProtKB/TrEMBL
    D4AAX6

  3. XM_017593888.3 → XP_017449377.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2

    UniProtKB/TrEMBL
    D4AAX6
    Related
    ENSRNOP00000019096.7

  4. XM_039111373.2 → XP_038967301.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X5

    Conserved Domains (4) summary
    cd08633
    Location:468 → 877
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02222
    Location:406 → 1017
    PLN02222; phosphoinositide phospholipase C 2
    cd13364
    Location:192 → 298
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:316 → 456
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)

  5. XM_039111372.2 → XP_038967300.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

    Conserved Domains (4) summary
    cd08633
    Location:468 → 877
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02222
    Location:406 → 1017
    PLN02222; phosphoinositide phospholipase C 2
    cd13364
    Location:192 → 298
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:316 → 456
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)

RNA

  1. XR_005505150.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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