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CHOp24 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31382, updated on 11-Apr-2024

Summary

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Official Symbol
CHOp24provided by FlyBase
Primary source
FLYBASE:FBgn0029709
Locus tag
Dmel_CG3564
See related
AllianceGenome:FB:FBgn0029709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3564; Dmel\CG3564; emp24; Emp24; p24; p24/p24beta1
Summary
Enables cargo receptor activity. Involved in Wnt protein secretion; endoplasmic reticulum to Golgi vesicle-mediated transport; and wing disc development. Located in endomembrane system. Is expressed in several structures, including anterior endoderm anlage; egg chamber; embryonic/larval midgut primordium; endoderm; and gut section. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
4C7-4C7; 1-8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4540908..4542506)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4434941..4436539)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32773 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ruby Neighboring gene Usf

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway. Li X, et al. Biochem Biophys Res Commun, 2015 Aug 7. PMID 26002470, Free PMC Article
  2. Drosophila Cornichon acts as cargo receptor for ER export of the TGFalpha-like growth factor Gurken. Bökel C, et al. Development, 2006 Feb. PMID 16396907
  3. p24 family proteins: key players in the regulation of trafficking along the secretory pathway. Pastor-Cantizano N, et al. Protoplasma, 2016 Jul. PMID 26224213
  4. Drosophila melanogaster p24 genes have developmental, tissue-specific, and sex-specific expression patterns and functions. Boltz KA, et al. Dev Dyn, 2007 Feb. PMID 17131401
  5. p24 proteins, intracellular trafficking, and behavior: Drosophila melanogaster provides insights and opportunities. Carney GE, et al. Biol Cell, 2004 May. PMID 15145531

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Emp24 and Eca act as specific cargo receptors for Wg to concentrate it in forming vesicles at sites of endoplasmic reticulum export.
    Title: A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cargo receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cargo receptor activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi vesicle transport ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
CHOp24
Names
CG3564-PA
CG3564-PB
CHOp24-PA
CHOp24-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4540908..4542506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297933.1 → NP_001284862.1  CHOp24, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284862.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W4K0
    Conserved Domains (1) summary
    pfam01105
    Location:24 → 203
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

  2. NM_131937.4 → NP_572165.1  CHOp24, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572165.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W4K0
    Related
    FBpp0070643
    Conserved Domains (1) summary
    pfam01105
    Location:24 → 203
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W4K0 Q9W4K0

Gene LinkOut

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