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Fam98a family with sequence similarity 98, member A [ Rattus norvegicus (Norway rat) ]

Gene ID: 313873, updated on 30-Mar-2024

Summary

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Official Symbol
Fam98aprovided by RGD
Official Full Name
family with sequence similarity 98, member Aprovided by RGD
Primary source
RGD:1305486
See related
Ensembl:ENSRNOG00000030328 AllianceGenome:RGD:1305486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305486
Summary
Predicted to enable protein methyltransferase activity. Predicted to be involved in several processes, including lysosome localization; positive regulation of ruffle assembly; and protein methylation. Predicted to be part of tRNA-splicing ligase complex. Orthologous to human FAM98A (family with sequence similarity 98 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 147.3), Muscle (RPKM 125.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (25626108..25640767)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (19874082..19888744)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (21051327..21065986)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ST13, Hsp70 interacting protein, pseudogene 3 Neighboring gene lactate dehydrogenase A, pseudogene 13 Neighboring gene RAS guanyl releasing protein 3 Neighboring gene ribosomal protein L32, pseudogene 18 Neighboring gene uncharacterized LOC120103479 Neighboring gene latent transforming growth factor beta binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression. Akter KA, et al. Int J Biochem Cell Biol, 2017 Mar. PMID 28040436
  2. PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. Fujiwara T, et al. JCI Insight, 2016 Oct 20. PMID 27777970, Free PMC Article
  3. Mapping the in vitro interactome of cardiac sodium (Na(+) )-calcium (Ca(2+) ) exchanger 1 (NCX1). Lubelwana Hafver T, et al. Proteomics, 2017 Sep. PMID 28755400
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC106015

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lysosome localization IEA
Inferred from Electronic Annotation
more info
  
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ruffle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of tRNA-splicing ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein FAM98A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014073.2 → NP_001014095.1  protein FAM98A

    See identical proteins and their annotated locations for NP_001014095.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q5FWT1
    UniProtKB/TrEMBL
    A6H9W9
    Related
    ENSRNOP00000042004.3, ENSRNOT00000052131.3
    Conserved Domains (1) summary
    pfam10239
    Location:11 → 327
    DUF2465; Protein of unknown function (DUF2465)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    25626108..25640767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261850.1 → XP_063117920.1  protein FAM98A isoform X1

  2. XM_039112160.2 → XP_038968088.1  protein FAM98A isoform X2

    Conserved Domains (1) summary
    pfam10239
    Location:3 → 133
    DUF2465; Protein of unknown function (DUF2465)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWT1.1 GenPept UniProtKB/Swiss-Prot:Q5FWT1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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