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CG7024 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31407, updated on 10-May-2024

Summary

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Official Symbol
CG7024provided by FlyBase
Primary source
FLYBASE:FBgn0029722
Locus tag
Dmel_CG7024
See related
AllianceGenome:FB:FBgn0029722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG7024
Summary
Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) and PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG7024 in Genome Data Viewer
Location:
4C14-4C14; 1-8 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4705309..4707504)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4599342..4601537)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene cut up Neighboring gene Pyruvate dehydrogenase E1 alpha subunit Neighboring gene Proctolin receptor Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster. Iranmehr A, et al. Nat Commun, 2021 Feb 12. PMID 33579965, Free PMC Article
  2. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. Huang Y, et al. PLoS Biol, 2013 Nov. PMID 24348200, Free PMC Article
  3. Systematic identification of functional orthologs based on protein network comparison. Bandyopadhyay S, et al. Genome Res, 2006 Mar. PMID 16510899, Free PMC Article
  4. Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster. Wicker-Thomas C, et al. J Lipid Res, 2015 Nov. PMID 26353752, Free PMC Article
  5. Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. Ringrose L, et al. Dev Cell, 2003 Nov. PMID 14602076

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
contributes_to pyruvate dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
part_of pyruvate dehydrogenase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7024-PA
NP_572182.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4705309..4707504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_131954.1 → NP_572182.1  uncharacterized protein Dmel_CG7024 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572182.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W4H4
    Related
    FBpp0070680, FBtr0070712
    Conserved Domains (1) summary
    cl01629
    Location:37 → 381
    TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W4H4 Q9W4H4

Gene LinkOut

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