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Tmem63c transmembrane protein 63c [ Rattus norvegicus (Norway rat) ]

Gene ID: 314332, updated on 2-May-2024

Summary

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Official Symbol
Tmem63cprovided by RGD
Official Full Name
transmembrane protein 63cprovided by RGD
Primary source
RGD:1310207
See related
Ensembl:ENSRNOG00000011334 AllianceGenome:RGD:1310207
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310207
Summary
Predicted to enable calcium activated cation channel activity and osmolarity-sensing cation channel activity. Involved in glomerular filtration. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM63C (transmembrane protein 63C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 59.7), Spleen (RPKM 20.5) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q31
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112398308..112469732)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106667389..106738778)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (111044099..111120659)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene CLOCK-interacting pacemaker Neighboring gene transfer RNA glycine (anticodon ACC) Neighboring gene zinc finger DHHC-type palmitoyltransferase 22 Neighboring gene neuroglobin Neighboring gene uncharacterized LOC134479237 Neighboring gene protein-O-mannosyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. Schulz A, et al. Elife, 2019 Mar 22. PMID 30900988, Free PMC Article
  2. DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes. Hou C, et al. Cell Res, 2014 May. PMID 24503647, Free PMC Article
  3. Co-expression of mouse TMEM63A, TMEM63B and TMEM63C confers hyperosmolarity activated ion currents in HEK293 cells. Zhao X, et al. Cell Biochem Funct, 2016 Jun. PMID 27045885
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tmem63c is differentially expressed in glomeruli of allele-specific rat models during onset of albuminuria.
    Title: Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-activated cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables osmolarity-sensing monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables osmolarity-sensing monoatomic cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glomerular filtration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
calcium permeable stress-gated cation channel 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108045.1 → NP_001101515.1  calcium permeable stress-gated cation channel 1

    See identical proteins and their annotated locations for NP_001101515.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473982
    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Related
    ENSRNOP00000015571.5, ENSRNOT00000015571.7
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    112398308..112469732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261951.1 → XP_063118021.1  calcium permeable stress-gated cation channel 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZNF5

  2. XM_006240384.4 → XP_006240446.1  calcium permeable stress-gated cation channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006240446.1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  3. XM_063261950.1 → XP_063118020.1  calcium permeable stress-gated cation channel 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZNF5

  4. XM_006240386.5 → XP_006240448.1  calcium permeable stress-gated cation channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006240448.1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  5. XM_063261948.1 → XP_063118018.1  calcium permeable stress-gated cation channel 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZNF5

  6. XM_039112327.2 → XP_038968255.1  calcium permeable stress-gated cation channel 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  7. XM_039112326.2 → XP_038968254.1  calcium permeable stress-gated cation channel 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  8. XM_006240385.5 → XP_006240447.1  calcium permeable stress-gated cation channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006240447.1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  9. XM_017594159.3 → XP_017449648.1  calcium permeable stress-gated cation channel 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  10. XM_006240382.5 → XP_006240444.1  calcium permeable stress-gated cation channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006240444.1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  11. XM_017594161.3 → XP_017449650.1  calcium permeable stress-gated cation channel 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  12. XM_006240389.5 → XP_006240451.1  calcium permeable stress-gated cation channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006240451.1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  13. XM_039112330.2 → XP_038968258.1  calcium permeable stress-gated cation channel 1 isoform X4

    Conserved Domains (3) summary
    pfam02714
    Location:407 → 515
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  14. XM_017594158.3 → XP_017449647.1  calcium permeable stress-gated cation channel 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  15. XM_006240383.5 → XP_006240445.1  calcium permeable stress-gated cation channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006240445.1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  16. XM_006240387.5 → XP_006240449.1  calcium permeable stress-gated cation channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006240449.1

    UniProtKB/Swiss-Prot
    D3ZNF5
    UniProtKB/TrEMBL
    A0A8L2QZP2
    Conserved Domains (3) summary
    pfam02714
    Location:407 → 678
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:38 → 195
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:218 → 396
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  17. XM_006240390.4 → XP_006240452.1  calcium permeable stress-gated cation channel 1 isoform X2

    Conserved Domains (2) summary
    pfam02714
    Location:217 → 556
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam14703
    Location:129 → 199
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  18. XM_039112328.2 → XP_038968256.1  calcium permeable stress-gated cation channel 1 isoform X3

    Conserved Domains (2) summary
    pfam02714
    Location:187 → 458
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam14703
    Location:1 → 176
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

RNA

  1. XR_010052096.1 RNA Sequence

  2. XR_005505527.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZNF5.1 GenPept UniProtKB/Swiss-Prot:D3ZNF5

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