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TrxT Thioredoxin T [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31443, updated on 10-May-2024

Summary

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Official Symbol
TrxTprovided by FlyBase
Official Full Name
Thioredoxin Tprovided by FlyBase
Primary source
FLYBASE:FBgn0029752
Locus tag
Dmel_CG3315
See related
AllianceGenome:FB:FBgn0029752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
3315; CG3315; DmelTrxT; Dmel\CG3315; DmTrxT; trxt; Trxt
Summary
Predicted to enable disulfide oxidoreductase activity. Involved in protein folding. Located in Y chromosome. Is expressed in organism; primary spermatocyte; spermatocyte; and testis. Orthologous to several human genes including TXN (thioredoxin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See TrxT in Genome Data Viewer
Location:
4F4-4F4; 1-11 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5310581..5311888, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5204614..5205921, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cyclin-dependent kinase 7 Neighboring gene sans fille Neighboring gene deadhead Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins. Freier R, et al. IUCrJ, 2021 Mar 1. PMID 33708404, Free PMC Article
  2. Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila. Umeda-Kameyama Y, et al. J Biol Chem, 2007 Apr 13. PMID 17301052
  3. Possible function of two insect phospholipid-hydroperoxide glutathione peroxidases. Li D, et al. J Insect Physiol, 2003 Jan. PMID 12770011
  4. Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity. AlOkda A, et al. Antioxidants (Basel), 2023 Apr 17. PMID 37107319, Free PMC Article
  5. Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila. Tsuda M, et al. FEBS Lett, 2010 Aug 4. PMID 20600005

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ThioredoxinT, a thioredoxin with testis-specific expression, has a clear association with the Y chromosome lampbrush loops ks-1 and kl-5 in primary spermatocytes
    Title: The ThioredoxinT and deadhead gene pair encode testis- and ovary-specific thioredoxins in Drosophila melanogaster.
  2. Drosophila thioredoxin can function as an anti-aging agent and as a suppressor of Parkin-associated endothelin receptor-like receptor - and poly-glutamine-induced neurotoxicity
    Title: Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Y chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thioredoxin T
Names
CG3315-PA
CG3315-PB
ThioredoxinT
TrxT-PA
TrxT-PB
thioredoxin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5310581..5311888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297952.1 → NP_001284881.1  thioredoxin T, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284881.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IFW4, Q9W4D6
    UniProtKB/TrEMBL
    X2JID2
    Conserved Domains (1) summary
    pfam00085
    Location:13 → 105
    Thioredoxin; Thioredoxin

  2. NM_131984.1 → NP_572212.1  thioredoxin T, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572212.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IFW4, Q9W4D6
    UniProtKB/TrEMBL
    X2JID2
    Related
    FBpp0070722, FBtr0070755
    Conserved Domains (1) summary
    pfam00085
    Location:13 → 105
    Thioredoxin; Thioredoxin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IFW4.1 Q8IFW4
X2JID2 X2JID2

Gene LinkOut

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