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Trmt61a tRNA methyltransferase 61A [ Rattus norvegicus (Norway rat) ]

Gene ID: 314462, updated on 11-Apr-2024

Summary

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Symbol
Trmt61aprovided by RGD
Full Name
tRNA methyltransferase 61Aprovided by RGD
Primary source
RGD:1359191
See related
Ensembl:ENSRNOG00000011398 AllianceGenome:RGD:1359191
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gcd14; Trm61; RGD1359191
Summary
Predicted to enable mRNA (adenine-N1-)-methyltransferase activity. Predicted to be involved in mRNA methylation and tRNA methylation. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Orthologous to human TRMT61A (tRNA methyltransferase 61A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 74.2), Brain (RPKM 50.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136558417..136564411)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130737230..130743251)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136150768..136156785)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene carnitine palmitoyltransferase 1A like 1 Neighboring gene microtubule affinity regulating kinase 3 Neighboring gene creatine kinase B Neighboring gene transfer RNA leucine (anticodon AAG) Neighboring gene BAG cochaperone 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Li X, et al. Mol Cell, 2017 Dec 7. PMID 29107537, Free PMC Article
  2. The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Safra M, et al. Nature, 2017 Nov 9. PMID 29072297
  3. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. Ozanick S, et al. RNA, 2005 Aug. PMID 16043508, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94251

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA (adenine-N1-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA (adenine-N1-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA (adenine(58)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA modification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Names
GCD14 and PCMT domain containing protein RGD1359191
GCD14/PCMT domain containing protein RGD1359191
mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A
tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61
tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A
tRNA methyltransferase 61 homolog A
tRNA(m1A58)-methyltransferase subunit TRM61
tRNA(m1A58)-methyltransferase subunit TRMT61A
tRNA(m1A58)MTase subunit TRM61
tRNA(m1A58)MTase subunit TRMT61A
NP_001007707.1
XP_008763160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007706.1 → NP_001007707.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

    See identical proteins and their annotated locations for NP_001007707.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079198
    UniProtKB/Swiss-Prot
    Q6AY46
    UniProtKB/TrEMBL
    A6KBS6
    Related
    ENSRNOP00000015308.2, ENSRNOT00000015308.4
    Conserved Domains (3) summary
    COG2519
    Location:9 → 290
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam08704
    Location:64 → 287
    GCD14; tRNA methyltransferase complex GCD14 subunit
    pfam14801
    Location:12 → 58
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    136558417..136564411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764938.4 → XP_008763160.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A isoform X1

    See identical proteins and their annotated locations for XP_008763160.1

    UniProtKB/Swiss-Prot
    Q6AY46
    UniProtKB/TrEMBL
    A6KBS6
    Conserved Domains (3) summary
    COG2519
    Location:9 → 290
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam08704
    Location:64 → 287
    GCD14; tRNA methyltransferase complex GCD14 subunit
    pfam14801
    Location:12 → 58
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY46.1 GenPept UniProtKB/Swiss-Prot:Q6AY46

Gene LinkOut

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