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Osgepl1 O-sialoglycoprotein endopeptidase-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314548, updated on 6-Jun-2024

Summary

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Official Symbol
Osgepl1provided by RGD
Official Full Name
O-sialoglycoprotein endopeptidase-like 1provided by RGD
Primary source
RGD:1305575
See related
Ensembl:ENSRNOG00000004001 AllianceGenome:RGD:1305575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be active in mitochondrion. Orthologous to human OSGEPL1 (O-sialoglycoprotein endopeptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 97.1), Muscle (RPKM 96.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Osgepl1 in Genome Data Viewer
Location:
9q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (55707389..55725325, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (48214995..48229440, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53084042..53098029, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 40 member 1 Neighboring gene proteolipid protein 2 like 1 Neighboring gene ASNSD1 upstream open reading frame Neighboring gene asparagine synthetase domain containing 1 Neighboring gene ankyrin and armadillo repeat containing Neighboring gene PMS1 homolog 1, mismatch repair system component Neighboring gene ORMDL sphingolipid biosynthesis regulator 1 Neighboring gene large ribosomal subunit protein eL37-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N(6)-L-threonylcarbamoyladenine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables N(6)-L-threonylcarbamoyladenine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables N(6)-L-threonylcarbamoyladenine synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA threonylcarbamoyladenosine modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA threonylcarbamoyladenosine modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA threonylcarbamoyladenosine modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
Names
N6-L-threonylcarbamoyladenine synthase
O-sialoglycoprotein endopeptidase-like protein 1
probable O-sialoglycoprotein endopeptidase 2
probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
t(6)A synthase
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1
tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
NP_001380997.1
NP_001380999.1
XP_038939388.1
XP_063123126.1
XP_063123127.1
XP_063123128.1
XP_063123129.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394068.1 → NP_001380997.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q4V7F3
    UniProtKB/TrEMBL
    A6INU3, Q6AYN7
    Related
    ENSRNOP00000005408.4, ENSRNOT00000005408.6
    Conserved Domains (1) summary
    TIGR03723
    Location:39 → 372
    T6A_TsaD_YgjD; tRNA threonylcarbamoyl adenosine modification protein TsaD

  2. NM_001394070.1 → NP_001380999.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q4V7F3
    UniProtKB/TrEMBL
    A6INU3, Q6AYN7
    Conserved Domains (1) summary
    TIGR03723
    Location:39 → 372
    T6A_TsaD_YgjD; tRNA threonylcarbamoyl adenosine modification protein TsaD

RNA

  1. NR_172073.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    55707389..55725325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267059.1 → XP_063123129.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X3

    UniProtKB/Swiss-Prot
    Q4V7F3
    UniProtKB/TrEMBL
    A6INU3, Q6AYN7

  2. XM_039083460.2 → XP_038939388.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X4

    Conserved Domains (1) summary
    TIGR03723
    Location:39 → 329
    T6A_TsaD_YgjD; tRNA threonylcarbamoyl adenosine modification protein TsaD

  3. XM_063267057.1 → XP_063123127.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y7X8, Q6AYN7

  4. XM_063267058.1 → XP_063123128.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q6AYN7

  5. XM_063267056.1 → XP_063123126.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y7X8, Q6AYN7

RNA

  1. XR_010054587.1 RNA Sequence

  2. XR_357008.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V7F3.1 GenPept UniProtKB/Swiss-Prot:Q4V7F3

Gene LinkOut

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