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Plk5 polo-like kinase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314627, updated on 6-Jun-2024

Summary

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Official Symbol
Plk5provided by RGD
Official Full Name
polo-like kinase 5provided by RGD
Primary source
RGD:1305038
See related
Ensembl:ENSRNOG00000034102 AllianceGenome:RGD:1305038
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Plk5p
Summary
Predicted to enable ATP binding activity. Predicted to be involved in several processes, including Golgi disassembly; defense response to tumor cell; and regulation of cell cycle process. Predicted to be located in nucleolus. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Orthologous to human PLK5 (polo like kinase 5 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 26.1), Thymus (RPKM 19.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plk5 in Genome Data Viewer
Location:
7q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9997453..10006959, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9346777..9367923, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12212910..12234253, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene mex-3 RNA binding family member D Neighboring gene ADAMTS-like 5 Neighboring gene receptor accessory protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. de Cárcer G, et al. Mol Cell Biol, 2011 Mar. PMID 21245385, Free PMC Article
  2. The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. Andrysik Z, et al. Nucleic Acids Res, 2010 May. PMID 20100802, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to tumor cell ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inactive serine/threonine-protein kinase PLK5
Names
polo-like kinase 5 pseudogene
serine/threonine-protein kinase PLK5
NP_001164028.1
XP_006240983.1
XP_006240984.1
XP_006240985.1
XP_006240987.1
XP_008763320.1
XP_008763321.1
XP_038934931.1
XP_038934933.1
XP_063119487.1
XP_063119488.1
XP_063119489.1
XP_063119490.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170557.1 → NP_001164028.1  inactive serine/threonine-protein kinase PLK5

    See identical proteins and their annotated locations for NP_001164028.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474029
    UniProtKB/TrEMBL
    A6K8L7, A6K8L8
    Conserved Domains (3) summary
    smart00220
    Location:27 → 279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:410 → 497
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14099
    Location:25 → 279
    STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9997453..10006959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240922.5 → XP_006240984.1  inactive serine/threonine-protein kinase PLK5 isoform X2

    UniProtKB/TrEMBL
    A6K8L8
    Conserved Domains (3) summary
    smart00220
    Location:27 → 279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:410 → 497
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14099
    Location:25 → 279
    STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

  2. XM_008765098.4 → XP_008763320.1  inactive serine/threonine-protein kinase PLK5 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:27 → 279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:429 → 516
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14099
    Location:25 → 279
    STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

  3. XM_063263417.1 → XP_063119487.1  inactive serine/threonine-protein kinase PLK5 isoform X6

  4. XM_006240923.5 → XP_006240985.1  inactive serine/threonine-protein kinase PLK5 isoform X4

    UniProtKB/TrEMBL
    A6K8L8
    Conserved Domains (3) summary
    smart00220
    Location:27 → 240
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:390 → 477
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:25 → 240
    PKc_like; Protein Kinases, catalytic domain

  5. XM_006240921.5 → XP_006240983.1  inactive serine/threonine-protein kinase PLK5 isoform X1

    UniProtKB/TrEMBL
    D3ZY07
    Related
    ENSRNOP00000051194.5
    Conserved Domains (3) summary
    smart00220
    Location:27 → 279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:429 → 516
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14099
    Location:25 → 279
    STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

  6. XM_063263418.1 → XP_063119488.1  inactive serine/threonine-protein kinase PLK5 isoform X7

    UniProtKB/TrEMBL
    A6K8L8

  7. XM_039079003.2 → XP_038934931.1  inactive serine/threonine-protein kinase PLK5 isoform X8

    UniProtKB/TrEMBL
    A6K8L8
    Conserved Domains (2) summary
    cd13118
    Location:344 → 431
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:1 → 194
    PKc_like; Protein Kinases, catalytic domain

  8. XM_008765099.4 → XP_008763321.1  inactive serine/threonine-protein kinase PLK5 isoform X5

    See identical proteins and their annotated locations for XP_008763321.1

    UniProtKB/TrEMBL
    A6K8L8
    Conserved Domains (3) summary
    smart00220
    Location:2 → 233
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:383 → 470
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:1 → 233
    PKc_like; Protein Kinases, catalytic domain

  9. XM_039079005.2 → XP_038934933.1  inactive serine/threonine-protein kinase PLK5 isoform X10

    Conserved Domains (1) summary
    cd13118
    Location:139 → 226
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

  10. XM_063263419.1 → XP_063119489.1  inactive serine/threonine-protein kinase PLK5 isoform X11

  11. XM_006240925.5 → XP_006240987.1  inactive serine/threonine-protein kinase PLK5 isoform X9

    See identical proteins and their annotated locations for XP_006240987.1

    Conserved Domains (3) summary
    smart00220
    Location:27 → 279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13118
    Location:429 → 467
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14099
    Location:25 → 279
    STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

  12. XM_063263420.1 → XP_063119490.1  inactive serine/threonine-protein kinase PLK5 isoform X12

RNA

  1. XR_355241.5 RNA Sequence

  2. XR_355240.5 RNA Sequence

  3. XR_005486602.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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