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Mon2 MON2 homolog, regulator of endosome-to-Golgi trafficking [ Rattus norvegicus (Norway rat) ]

Gene ID: 314894, updated on 4-Apr-2024

Summary

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Official Symbol
Mon2provided by RGD
Official Full Name
MON2 homolog, regulator of endosome-to-Golgi traffickingprovided by RGD
Primary source
RGD:1308808
See related
Ensembl:ENSRNOG00000004185 AllianceGenome:RGD:1308808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308808
Summary
Predicted to be involved in protein transport. Predicted to be located in early endosome membrane. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 200.0), Kidney (RPKM 185.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mon2 in Genome Data Viewer
Location:
7q22
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (60534772..60613467, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (58649378..58728102, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (66717470..66794041)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1H Neighboring gene uncharacterized LOC134479883 Neighboring gene nascent polypeptide-associated complex subunit alpha, muscle-specific form-like Neighboring gene microRNA let-7i Neighboring gene SNRPN upstream reading frame protein-like Neighboring gene SNRPN upstream open reading frame like 1 Neighboring gene uncharacterized LOC134479704 Neighboring gene ubiquitin specific peptidase 15 Neighboring gene small nucleolar RNA, H/ACA box 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125084

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Golgi to endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein MON2 homolog
Names
MON2 regulator of endosome-to-Golgi trafficking

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040176.4 → NP_001035266.2  protein MON2 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D3ZKH2
    Conserved Domains (4) summary
    pfam09324
    Location:869 → 928
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:211 → 378
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:931 → 1699
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9 → 183
    DCB; Dimerization and cyclophilin-binding domain of Mon2

  2. NM_001414945.2 → NP_001401874.1  protein MON2 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D3ZCG3
    Related
    ENSRNOP00000005654.5, ENSRNOT00000005654.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    60534772..60613467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263503.1 → XP_063119573.1  protein MON2 homolog isoform X1

  2. XM_063263504.1 → XP_063119574.1  protein MON2 homolog isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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