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Nop2 NOP2 nucleolar protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 314969, updated on 30-Mar-2024

Summary

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Official Symbol
Nop2provided by RGD
Official Full Name
NOP2 nucleolar proteinprovided by RGD
Primary source
RGD:1304616
See related
Ensembl:ENSRNOG00000018453 AllianceGenome:RGD:1304616
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nol1
Summary
Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Predicted to be involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosome biogenesis. Predicted to act upstream of or within blastocyst formation. Predicted to be active in nucleolus. Orthologous to human NOP2 (NOP2 nucleolar protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 52.6), Thymus (RPKM 45.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q42
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159618894..159630697)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157932731..157944462)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157646759..157658502)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 4 Neighboring gene uncharacterized LOC120102389 Neighboring gene small Cajal body-specific RNA 11 Neighboring gene intermediate filament family orphan 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation. Valdez BC, et al. Cancer Res, 1992 Oct 15. PMID 1394192
  2. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. Sloan KE, et al. Cell Rep, 2013 Oct 17. PMID 24120868, Free PMC Article
  3. Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Sigal A, et al. Nat Methods, 2006 Jul. PMID 16791210
  4. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (cytosine-C5-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
Names
NOP2 nucleolar protein homolog
nucleolar protein 1
putative ribosomal RNA methyltransferase NOP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191785.1 → NP_001178714.1  probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    D4ACW1
    Related
    ENSRNOP00000024938.6, ENSRNOT00000024938.8
    Conserved Domains (2) summary
    TIGR00446
    Location:292 → 566
    nop2p; NOL1/NOP2/sun family putative RNA methylase
    PRK10905
    Location:573 → 761
    PRK10905; cell division protein DamX; Validated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159618894..159630697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286195.1 → XP_063142265.1  probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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