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Prr5 proline rich 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315189, updated on 5-Mar-2024

Summary

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Official Symbol
Prr5provided by RGD
Official Full Name
proline rich 5provided by RGD
Primary source
RGD:1307954
See related
Ensembl:ENSRNOG00000069507 AllianceGenome:RGD:1307954
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Protor1
Summary
Predicted to be involved in TORC2 signaling. Predicted to act upstream of or within positive regulation of phosphatidylinositol 3-kinase signaling and positive regulation of protein phosphorylation. Predicted to be part of TORC2 complex. Orthologous to human PRR5 (proline rich 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 47.6), Spleen (RPKM 21.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prr5 in Genome Data Viewer
Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (117675308..117717833)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (115795351..115837880)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (125569791..125609340)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene basic transcription factor 3 like 6 Neighboring gene Rho GTPase activating protein 8 Neighboring gene PHD finger protein 21B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Gan X, et al. Nat Cell Biol, 2012 May 20. PMID 22609986, Free PMC Article
  2. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Pearce LR, et al. Biochem J, 2011 May 15. PMID 21413931
  3. mTOR signaling in growth control and disease. Laplante M, et al. Cell, 2012 Apr 13. PMID 22500797, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC109513

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proline-rich protein 5
Names
proline rich 5 (renal)
protein observed with Rictor-1
protor-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012121.1 → NP_001012121.1  proline-rich protein 5

    See identical proteins and their annotated locations for NP_001012121.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090007
    UniProtKB/Swiss-Prot
    Q5FVG6
    Related
    ENSRNOP00000095214.1, ENSRNOT00000117245.1
    Conserved Domains (2) summary
    PHA03326
    Location:224 → 326
    PHA03326; nuclear egress membrane protein; Provisional
    pfam08539
    Location:40 → 159
    HbrB; HbrB-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    117675308..117717833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765726.3 → XP_008763948.1  proline-rich protein 5 isoform X2

    See identical proteins and their annotated locations for XP_008763948.1

    UniProtKB/TrEMBL
    A0A0H2UHJ6
    Conserved Domains (2) summary
    PHA03326
    Location:215 → 317
    PHA03326; nuclear egress membrane protein; Provisional
    pfam08539
    Location:31 → 150
    HbrB; HbrB-like

  2. XM_063263625.1 → XP_063119695.1  proline-rich protein 5 isoform X2

  3. XM_017594872.3 → XP_017450361.1  proline-rich protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHJ6
    Conserved Domains (2) summary
    PHA03326
    Location:215 → 317
    PHA03326; nuclear egress membrane protein; Provisional
    pfam08539
    Location:31 → 150
    HbrB; HbrB-like

  4. XM_008765722.4 → XP_008763944.1  proline-rich protein 5 isoform X2

    See identical proteins and their annotated locations for XP_008763944.1

    UniProtKB/TrEMBL
    A0A0H2UHJ6
    Conserved Domains (2) summary
    PHA03326
    Location:215 → 317
    PHA03326; nuclear egress membrane protein; Provisional
    pfam08539
    Location:31 → 150
    HbrB; HbrB-like

  5. XM_039079293.2 → XP_038935221.1  proline-rich protein 5 isoform X1

    Conserved Domains (2) summary
    PHA03326
    Location:221 → 323
    PHA03326; nuclear egress membrane protein; Provisional
    pfam08539
    Location:40 → 159
    HbrB; HbrB-like

  6. XM_008765723.4 → XP_008763945.1  proline-rich protein 5 isoform X3

    See identical proteins and their annotated locations for XP_008763945.1

    UniProtKB/TrEMBL
    A6HTC1
    Conserved Domains (2) summary
    PHA03326
    Location:128 → 230
    PHA03326; nuclear egress membrane protein; Provisional
    pfam08539
    Location:1 → 63
    HbrB; HbrB-like

  7. XM_008765725.4 → XP_008763947.1  proline-rich protein 5 isoform X3

    See identical proteins and their annotated locations for XP_008763947.1

    UniProtKB/TrEMBL
    A6HTC1
    Conserved Domains (2) summary
    PHA03326
    Location:128 → 230
    PHA03326; nuclear egress membrane protein; Provisional
    pfam08539
    Location:1 → 63
    HbrB; HbrB-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVG6.1 GenPept UniProtKB/Swiss-Prot:Q5FVG6

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