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Racgap1 Rac GTPase-activating protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315298, updated on 11-Apr-2024

Summary

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Symbol
Racgap1provided by RGD
Full Name
Rac GTPase-activating protein 1provided by RGD
Primary source
RGD:1305912
See related
Ensembl:ENSRNOG00000049033 AllianceGenome:RGD:1305912
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and tubulin binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; mitotic spindle midzone assembly; and regulation of cell cycle process. Predicted to act upstream of or within neuroblast proliferation. Predicted to be located in several cellular components, including cleavage furrow; midbody; and spindle. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be part of centralspindlin complex. Orthologous to human RACGAP1 (Rac GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 167.6), Spleen (RPKM 104.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132629789..132659738, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130750936..130780891, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141277303..141308849, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene aquaporin 5 Neighboring gene aquaporin 6 Neighboring gene uncharacterized LOC134479572 Neighboring gene acid sensing ion channel subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Lekomtsev S, et al. Nature, 2012 Dec 13. PMID 23235882
  2. MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. Hirose K, et al. J Biol Chem, 2001 Feb 23. PMID 11085985
  3. Structure and expression of murine mgcRacGAP: its developmental regulation suggests a role for the Rac/MgcRacGAP signalling pathway in neurogenesis. Arar C, et al. Biochem J, 1999 Oct 1. PMID 10493933, Free PMC Article
  4. Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development. Van de Putte T, et al. Mech Dev, 2001 Apr. PMID 11287179
  5. MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Kawashima T, et al. Blood, 2000 Sep 15. PMID 10979956

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin contractile ring assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle midzone assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfate transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of centralspindlin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of centralspindlin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rac GTPase-activating protein 1
Names
rac GTPase-activating protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108112.1 → NP_001101582.1  rac GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_001101582.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474035
    UniProtKB/TrEMBL
    A0A8I5ZS98, A0A9K3Y6X7, B2GV02, M0RDX1
    Related
    ENSRNOP00000067834.2, ENSRNOT00000071885.3
    Conserved Domains (2) summary
    cd00029
    Location:286 → 334
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:345 → 538
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    132629789..132659738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257400.5 → XP_006257462.1  rac GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006257462.1

    UniProtKB/TrEMBL
    A0A8I5ZS98, A0A9K3Y6X7, B2GV02, M0RDX1
    Related
    ENSRNOP00000081316.1
    Conserved Domains (2) summary
    cd00029
    Location:286 → 334
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:345 → 538
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

  2. XM_039079329.2 → XP_038935257.1  rac GTPase-activating protein 1 isoform X2

    Conserved Domains (2) summary
    cd04382
    Location:169 → 362
    RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...
    cd20821
    Location:108 → 161
    C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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