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Krt4 keratin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315323, updated on 5-Jun-2021

Summary

Official Symbol
Krt4provided by RGD
Official Full Name
keratin 4provided by RGD
Primary source
RGD:1359272
See related
Ensembl:ENSRNOG00000032332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
K4; Kb4; CK-4
Expression
Restricted expression toward (RPKM 1061.0) See more
Orthologs
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Genomic context

See Krt4 in Genome Data Viewer
Location:
7q36
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133046067..133052027, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143517562..143523522, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene keratin 77 Neighboring gene keratin 76 Neighboring gene keratin 79 Neighboring gene keratin 78

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
keratin, type II cytoskeletal 4
Names
cytokeratin-4
keratin 4, type II
type-II keratin Kb4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008806.2NP_001008806.2  keratin, type II cytoskeletal 4

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000187
    Related
    ENSRNOP00000073894.1, ENSRNOT00000082264.1
    Conserved Domains (2) summary
    pfam00038
    Location:146456
    Filament; Intermediate filament protein
    pfam16208
    Location:14142
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    133046067..133052027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242395.4XP_006242457.1  keratin, type II cytoskeletal 4 isoform X2

    Conserved Domains (2) summary
    pfam00038
    Location:146458
    Filament; Intermediate filament protein
    pfam16208
    Location:14142
    Keratin_2_head; Keratin type II head
  2. XM_039079345.1XP_038935273.1  keratin, type II cytoskeletal 4 isoform X1

    Conserved Domains (1) summary
    pfam00038
    Location:1197
    Filament; Intermediate filament protein
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