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Krt4 keratin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315323, updated on 13-Apr-2024

Summary

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Official Symbol
Krt4provided by RGD
Official Full Name
keratin 4provided by RGD
Primary source
RGD:1359272
See related
Ensembl:ENSRNOG00000032332 AllianceGenome:RGD:1359272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
K4; Kb4; CK-4
Summary
Predicted to be involved in cytoskeleton organization; epithelial cell differentiation; and negative regulation of epithelial cell proliferation. Predicted to be located in cell surface and keratin filament. Human ortholog(s) of this gene implicated in hereditary mucosal leukokeratosis. Orthologous to human KRT4 (keratin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 1061.0) See more
Orthologs
human all
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Genomic context

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Location:
7q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134924753..134931050, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133046067..133052027, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143517562..143523522, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene keratin 77 Neighboring gene keratin 76 Neighboring gene keratin 79 Neighboring gene keratin 78

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The surface protein Srr-1 of Streptococcus agalactiae binds human keratin 4 and promotes adherence to epithelial HEp-2 cells. Samen U, et al. Infect Immun, 2007 Nov. PMID 17709412, Free PMC Article
  2. Mouse keratin 4 is necessary for internal epithelial integrity. Ness SL, et al. J Biol Chem, 1998 Sep 11. PMID 9727004
  3. A mutation in the mucosal keratin K4 is associated with oral white sponge nevus. Rugg EL, et al. Nat Genet, 1995 Dec. PMID 7493030
  4. Identification of cytokeratin subspecies altered in rat experimental esophageal tumors by subtractive cloning. Wang DY, et al. Cancer Lett, 1996 Nov 12. PMID 8950218
  5. Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis. Sakamoto K, et al. Histopathology, 2011 Mar. PMID 21371075

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
  
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
keratin, type II cytoskeletal 4
Names
cytokeratin-4
keratin 4, type II
type-II keratin Kb4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008806.2 → NP_001008806.2  keratin, type II cytoskeletal 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q6IG00
    Conserved Domains (2) summary
    pfam00038
    Location:146 → 456
    Filament; Intermediate filament protein
    pfam16208
    Location:14 → 142
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    134924753..134931050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242395.5 → XP_006242457.1  keratin, type II cytoskeletal 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6IG00
    UniProtKB/TrEMBL
    A0A0G2K6P7
    Related
    ENSRNOP00000073894.2
    Conserved Domains (2) summary
    pfam00038
    Location:146 → 458
    Filament; Intermediate filament protein
    pfam16208
    Location:14 → 142
    Keratin_2_head; Keratin type II head

  2. XM_039079345.2 → XP_038935273.1  keratin, type II cytoskeletal 4 isoform X2

    UniProtKB/TrEMBL
    A6KCR8
    Conserved Domains (1) summary
    pfam00038
    Location:1 → 197
    Filament; Intermediate filament protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IG00.1 GenPept UniProtKB/Swiss-Prot:Q6IG00

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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