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Ube4a ubiquitination factor E4A [ Rattus norvegicus (Norway rat) ]

Gene ID: 315608, updated on 11-Apr-2024

Summary

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Official Symbol
Ube4aprovided by RGD
Official Full Name
ubiquitination factor E4Aprovided by RGD
Primary source
RGD:1303173
See related
Ensembl:ENSRNOG00000026833 AllianceGenome:RGD:1303173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab2-232
Summary
Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent ERAD pathway. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBE4A (ubiquitination factor E4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 230.2), Liver (RPKM 203.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54132799..54174921, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45236022..45278129, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49229713..49271894, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) 38 Neighboring gene ATP synthase membrane subunit G Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A, pseudogene 1 Neighboring gene CD3 gamma subunit of T-cell receptor complex Neighboring gene CD3 delta subunit of T-cell receptor complex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues. Contino G, et al. Gene, 2004 Mar 17. PMID 15019985
  2. Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors. Alzayady KJ, et al. J Biol Chem, 2005 Oct 14. PMID 16103111, Free PMC Article
  3. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. Meyer HH, et al. EMBO J, 2000 May 15. PMID 10811609, Free PMC Article
  4. U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama S, et al. J Biol Chem, 2001 Aug 31. PMID 11435423
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-ubiquitin ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin conjugation factor E4 A
Names
RING-type E3 ubiquitin transferase E4 A
ubiquitination factor E4A (UFD2 homolog, yeast)
ubiquitination factor E4A, UFD2 homolog
NP_997493.2
XP_006243000.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207610.3 → NP_997493.2  ubiquitin conjugation factor E4 A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q6P7A2
    UniProtKB/TrEMBL
    F1M9N5
    Related
    ENSRNOP00000021321.4, ENSRNOT00000021321.6
    Conserved Domains (2) summary
    cd16657
    Location:990 → 1059
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:330 → 971
    Ufd2P_core; Ubiquitin elongating factor core

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    54132799..54174921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242938.5 → XP_006243000.1  ubiquitin conjugation factor E4 A isoform X1

    See identical proteins and their annotated locations for XP_006243000.1

    UniProtKB/Swiss-Prot
    Q6P7A2
    UniProtKB/TrEMBL
    Q7TP51
    Conserved Domains (3) summary
    COG5113
    Location:189 → 1080
    UFD2; Ubiquitin fusion degradation protein 2 [Posttranslational modification, protein turnover, chaperones]
    pfam04564
    Location:1007 → 1079
    U-box; U-box domain
    pfam10408
    Location:349 → 990
    Ufd2P_core; Ubiquitin elongating factor core
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P7A2.1 GenPept UniProtKB/Swiss-Prot:Q6P7A2

Gene LinkOut

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