Fum2 Fumarase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fum2provided by FlyBase
Official Full Name: Fumarase 2provided by FlyBase
Primary source: FLYBASE:FBgn0029890
Locus tag: Dmel_CG4095
See related: AllianceGenome:FB:FBgn0029890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4095; Dmel\CG4095
Summary: Predicted to enable fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Predicted to be part of tricarboxylic acid cycle enzyme complex. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6681767..6683696)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6575800..6577729)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables fumarate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fumarate hydratase activity	IEA Inferred from Electronic Annotation more info
enables fumarate hydratase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fumarate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fumarate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in malate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
part_of tricarboxylic acid cycle heteromeric enzyme complex	IEA Inferred from Electronic Annotation more info

NP_727109.2

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